{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:50:46Z","timestamp":1784026246845,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This survey was conducted to describe current European postnatal prophylaxis (PNP) and infant feeding policies with the aim of informing future harmonized guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 32 senior clinicians with relevant expertise, working in 20 countries within the European Region, were invited to complete a REDCap questionnaire between July and September 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three of the 32 invited paediatricians responded, representing 16\/20 countries. There were multiple respondents from the same country for Italy (<jats:italic>n<\/jats:italic>\u2009=\u20095), the UK (<jats:italic>n<\/jats:italic>\u2009=\u20092), Germany (<jats:italic>n<\/jats:italic>\u2009=\u20092) and France (<jats:italic>n<\/jats:italic>\u2009=\u20092). All countries use risk stratification to guide PNP regimen selection. Nine out of 16 countries reported three risk categories, six out of 16 reported two, and one country reported differences in categorization. Criteria used to stratify risk varied between and within countries. For the lowest risk category, the PNP regimen reported ranged from no PNP to up to four\u2009weeks of one drug; the drug of choice reported was zidovudine, apart from one country which reported nevirapine. For the highest risk category, the most common regimen was zidovudine\/lamivudine\/nevirapine (20\/23 respondents); regimen duration varied from two\u00a0to six\u2009weeks with variation in recommended dosing. Guidelines support breastfeeding for infants born to people living with HIV in eight out of 16 countries; in the other eight, guidelines do not support\/specify.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Guidelines and practice for PNP and infant feeding vary substantially across Europe and within some countries, reflecting the lack of robust evidence. Effort is needed to align policies and practice to reflect up\u2010to\u2010date knowledge to ensure the vertical transmission risk is minimized and unnecessary infant HIV testing and PNP avoided, while simultaneously supporting families to make informed decisions on infant feeding choice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13723","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T05:44:08Z","timestamp":1729748648000},"page":"207-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>HIV<\/scp> postnatal prophylaxis and infant feeding policies vary across Europe: results of a Penta survey"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2056-8376","authenticated-orcid":false,"given":"Georgina","family":"Fernandes","sequence":"first","affiliation":[{"name":"Population, Policy and Practice Research and Teaching Department UCL Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-6434","authenticated-orcid":false,"given":"Elizabeth","family":"Chappell","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit at UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Goetghebuer","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Pierre Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0784-3276","authenticated-orcid":false,"given":"Christian R.","family":"Kahlert","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Hospital Epidemiology Children's Hospital of Eastern Switzerland  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santa","family":"Ansone","sequence":"additional","affiliation":[{"name":"Outpatient Department, Riga East University Hospital Latvian Centre of Infectious Diseases  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Simplex Unit: Perinatal and Complex Infectious Disease \u2013 University Paediatric Clinical Area Bambino Ges\u00f9 Children's Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Castelli Gattinara","sequence":"additional","affiliation":[{"name":"Simplex Unit: Perinatal and Complex Infectious Disease \u2013 University Paediatric Clinical Area Bambino Ges\u00f9 Children's Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1476-4752","authenticated-orcid":false,"given":"Elena","family":"Chiappini","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Meyer Children's University Hospital IRCCS  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Dollfus","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9mato\u2010Oncologie P\u00e9diatrique APHP, Hopital Trousseau  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-8369","authenticated-orcid":false,"given":"Pierre","family":"Frange","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology Necker Enfants Malades Hospital, Groupe hospitalier APHP. 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