{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:55:53Z","timestamp":1785390953239,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019125","name":"Sorbonne Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Assessing the potential increased risk of viral rebound (VR) in migrants requires adequate control for sex and acquisition risk groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>People living with HIV1, enrolled in the ANRS CO4\u2010French Hospital Database on HIV, who achieved virological suppression with antiretroviral therapy (ART) initiated between 2006 and 2016 were included. We first compared the risk of VR, with loss to follow\u2010up and death considered as competing events, across origin among the HIV acquisition groups, then across acquisition groups among the different origins, and finally across modality of a variable combining sex, acquisition group, and origin. Models were adjusted for clinical and biological confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 21\u2009571 French natives (FRA), 10\u2009148 migrants from sub\u2010Saharan Africa (SSA), 1137 migrants from the non\u2010French West Indies (NFWI), and 4205 other migrants (OTHER). The 5\u2010year probability of VR was 19% (95% confidence interval [CI] 19\u201320) overall, 15% in FRA, 21% in OTHER, 26% in SSA, and 34% in NFWI (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). It was 14% in men who have sex with men (MSM), 23% in heterosexual men, and 23% in women (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). After adjustment, all acquisition groups had a higher risk of VR than MSM from FRA, with men and women from NFWI having the highest risk (adjusted hazard ratio [aHR] 2.46; 95% CI 2.12\u20132.86 and aHR 2.59; 95% CI 2.20\u20133.04, respectively). Within each acquisition group, all groups of origin had a higher risk of VR than FRA. Within each region of origin, except the NFWI, heterosexual men had a higher risk of VR than MSM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After accounting for sex and acquisition group, migration, especially from NFWI, remains prognostic of VR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13729","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T07:03:27Z","timestamp":1730790207000},"page":"252-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Viral rebound on antiretroviral therapy in France according to region of origin, sex, and <scp>HIV<\/scp> acquisition group. Results from the French Hospital Database on <scp>HIV<\/scp> (<scp>ANRS CO4<\/scp>\u2010<scp>FHDH<\/scp>)"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7891-7594","authenticated-orcid":false,"given":"S.","family":"Abgrall","sequence":"first","affiliation":[{"name":"AP\u2010HP, H\u00f4pital B\u00e9cl\u00e8re, Service de M\u00e9decine Interne, Clamart, and Universit\u00e9 Paris\u2010Saclay, CESP INSERM U1018  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Selinger\u2010Leneman","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lanoy","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Becker","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital de la Croix\u2010Rousse  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Matheron","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Bichat\u2010Claude Bernard, GHU Paris Nord  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"de Truchis","sequence":"additional","affiliation":[{"name":"AP\u2010HP H\u00f4pital Raymond Poincar\u00e9, Universit\u00e9 Paris\u2010Saclay  Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pavie","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4tel\u2010Dieu  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Canestri","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Khuong","sequence":"additional","affiliation":[{"name":"H\u00f4pital Delafontaine  Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Rey","sequence":"additional","affiliation":[{"name":"Strasbourg University Hospital  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Caby","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique  Paris France"},{"name":"H\u00f4pital Victor Dupouy  Argenteuil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Tattevin","sequence":"additional","affiliation":[{"name":"Pontchaillou University Hospital  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Palich","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, and AP\u2010HP, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4816-4261","authenticated-orcid":false,"given":"S.","family":"Grabar","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, AP\u2010HP, H\u00f4pital St Antoine  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ANRS CO4\u2010FHDH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000255079.39352.9b"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.10.026"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001193"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12536"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318245c9ca"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002942"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1818"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu002"},{"key":"e_1_2_9_11_1","volume-title":"Medical Care for People Infected with HIV","author":"Morlat P","year":"2013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans\u20102024\u2010056198"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae147"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000544"},{"key":"e_1_2_9_15_1","first-page":"1","article-title":"International migrations in Europe: towards harmonization of statistics","volume":"442","author":"Thierry X","year":"2008","journal-title":"INED Populat Soc"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12491"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10903\u2010019\u201000864\u2010y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000524"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001335"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744\u20108603\u20105\u20107"},{"key":"e_1_2_9_22_1","first-page":"293","article-title":"et le groupe Vespa2. Situation socio\u00e9conomique des personnes vivant avec le VIH suivies \u00e0 l'h\u00f4pital en France m\u00e9tropolitaine en 2011. Premiers r\u00e9sultats de l'enqu\u00eate ANRSVespa2","volume":"26","author":"Lert F","year":"2013","journal-title":"Bull Epid\u00e9miol Hebd."},{"key":"e_1_2_9_23_1","first-page":"749","article-title":"Caract\u00e9ristiques sociales et comportementales des personnes s\u00e9ropositives pour le VIH d\u00e9c\u00e9d\u00e9es en 2010 en France m\u00e9tropolitaine: quelles implications pour la prise en charge?","volume":"41","author":"Lert F","year":"2016","journal-title":"Bull Epid\u00e9miol Hebd"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2014.12.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz999"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad007"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(16)30002\u20100"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3339"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25485"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx300"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506816"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T13:21:03Z","timestamp":1738416063000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/hiv.13729"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13729","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,4]]},"assertion":[{"value":"2024-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}