{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:36:27Z","timestamp":1770748587030,"version":"3.50.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018336","name":"National Institute for Health Research Health Protection Research Unit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The survival rate of people with HIV admitted to intensive care units (ICUs) is approaching that of people without HIV. We conducted a matched\u2010cohort study of people with and without HIV admitted to ICU at a large hospital to compare short\u2010term mortality, during 2000\u20132019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>People with HIV were matched to people without HIV (1:2) on age, sex, admission year and Acute Physiology and Chronic Health Evaluation (APACHE)\u2010II score. Applying logistic regression models fitted using independence estimating equations, we describe population\u2010averaged associations of HIV with short\u2010term (in\u2010ICU, in\u2010hospital) mortality during a patient's first admission to ICU, and explore whether these varied by year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 177 people with HIV were matched to 354 people without HIV (71.2% vs. 71.2% male; median age: 47 vs. 48\u2009years, median APACHE\u2010II: 18 vs. 17, median admission year: 2013 vs. 2013). Among people with HIV, 73.4% were on antiretroviral therapy, 51.2% had HIV\u2010RNA \u226450 copies\/mL and median CD4 T\u2010cell count was 132 cells\/L. People with HIV had higher in\u2010ICU (24.3% vs. 15.3%) and in\u2010hospital (31.6% vs. 20.1%) mortality. People with HIV had 1.69\u2010fold higher odds (95% confidence interval: 1.03\u20132.76) of in\u2010ICU mortality and 1.86 (1.19\u20132.91) higher odds of in\u2010hospital mortality than people without HIV, adjusted for age, sex, year and APACHE\u2010II. There was no evidence that these associations varied by year (<jats:italic>p<\/jats:italic>\u2010interaction\u2010in\u2010ICU\u2009=\u20090.90; <jats:italic>p<\/jats:italic>\u2010interaction\u2010in\u2010hospital\u2009=\u20090.46).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that although outcomes have improved over time, people with HIV continue to have higher short\u2010term in\u2010ICU and in\u2010hospital mortality following ICU admission compared with people without HIV with similar characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13737","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T02:29:18Z","timestamp":1732156158000},"page":"275-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparing short\u2010term mortality between people with and without <scp>HIV<\/scp> admitted to the intensive care unit: A single\u2010centre matched cohort study (2000\u20132019)"],"prefix":"10.1111","volume":"26","author":[{"given":"N.","family":"Bakewell","sequence":"first","affiliation":[{"name":"Institute for Global Health University College London  London UK"},{"name":"National Institute for Health and Care Research (NIHR) Health Protection Research Unit (HPRU) in Blood Borne and Sexually Transmitted Infections University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kanitkar","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Royal Free Hospital, Royal Free London NHS Foundation Trust  London UK"},{"name":"HIV Services Royal Free Hospital, Royal Free London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Dissanayake","sequence":"additional","affiliation":[{"name":"HIV Services Royal Free Hospital, Royal Free London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Symonds","sequence":"additional","affiliation":[{"name":"HIV Services Royal Free Hospital, Royal Free London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rimmer","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Royal Free Hospital, Royal Free London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Adlakha","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Royal Free Hospital, Royal Free London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Lipman","sequence":"additional","affiliation":[{"name":"HIV Services Royal Free Hospital, Royal Free London NHS Foundation Trust  London UK"},{"name":"UCL Respiratory, Division of Medicine University College London  London UK"},{"name":"Respiratory Medicine Royal Free Hospital, Royal Free London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bhagani","sequence":"additional","affiliation":[{"name":"HIV Services Royal Free Hospital, Royal Free London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Royal Free Hospital, Royal Free London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. F.","family":"Miller","sequence":"additional","affiliation":[{"name":"HIV Services Royal Free Hospital, Royal Free London NHS Foundation Trust  London UK"},{"name":"Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5173-2760","authenticated-orcid":false,"given":"C. A.","family":"Sabin","sequence":"additional","affiliation":[{"name":"Institute for Global Health University College London  London UK"},{"name":"National Institute for Health and Care Research (NIHR) Health Protection Research Unit (HPRU) in Blood Borne and Sexually Transmitted Infections University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066618803871"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05945-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000029750"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003683"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9056"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3481-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6806"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2011.987"},{"issue":"4","key":"e_1_2_10_10_1","first-page":"1","article-title":"Mortality of patients infected with HIV in the intensive care unit (2005 through 2010): significant role of chronic hepatitis C and severe sepsis","volume":"18","author":"Medrano J","year":"2014","journal-title":"Crit Care"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1469-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2011.010496"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13436"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/pan\/mpr013"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1214\/12-STS390"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5879"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7136.989"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2008.11.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017090"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12695"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2111025"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11212"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2254-7"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7954"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(16)30020-2"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003019"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2652-12-15"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.1.138"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.4.541"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-023-01171-4"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014584"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005269"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005051"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T13:20:55Z","timestamp":1738416055000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/hiv.13737"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13737","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]},"assertion":[{"value":"2024-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}