{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T04:18:09Z","timestamp":1743913089793,"version":"3.40.3"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To measure concentrations of tenofovir diphosphate (TFV\u2010DP) in dried blood spots (DBS) among individuals taking tenofovir disoproxil fumarate plus emtricitabine (TDF\/FTC) or tenofovir alafenamide plus emtricitabine (TAF\/FTC) who were scheduled to undergo or had already undergone bariatric surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled pre\u2010exposure prophylaxis (PrEP) users attending clinics in Toronto or Ottawa who were undergoing or had undergone bariatric surgery. After participants completed a minimum of 7\u2009days of consecutive PrEP dosing, we collected DBS samples immediately before they administered their next daily dose of PrEP. Participants who had already undergone bariatric surgery before enrolment provided a single sample at baseline only. One participant undergoing planned bariatric surgery provided samples preoperatively and on postoperative days 7, 28 and 84. TFV\u2010DP was measured by liquid chromatography tandem mass spectrometry. We compared results against the population range TFV\u2010DP at varying degrees of adherence and stratified by chronology of bariatric surgery, type of bariatric surgery and PrEP regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of seven eligible participants, all were gay, cis\u2010gender men. Median age was 48\u2009years (Q1\u2013Q3:\u200944\u201351). Six participants underwent bariatric surgery before enrolment: four Roux\u2010en\u2010Y gastric bypass (RYGB) and two sleeve gastrectomy (SG). Four were taking TDF\/FTC and two were taking TAF\/FTC. All had therapeutic TFV\u2010DP concentrations, except for one TDF\/FTC participant who underwent SG. One participant taking TAF\/FTC enrolled before receiving RYGB and displayed a slight decrease in TFV\u2010DP over time, although all concentrations remained in the therapeutic range.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tenofovir diphosphate concentrations were at or near therapeutic values in this small sample of men using oral PrEP who underwent RYGB or SG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13759","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T11:46:32Z","timestamp":1736941592000},"page":"643-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intracellular tenofovir\u2010diphosphate concentrations in <scp>HIV<\/scp> pre\u2010exposure prophylaxis users who underwent bariatric surgery"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6663-0457","authenticated-orcid":false,"given":"Matthew W.","family":"McGarrity","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases St. Michael's Hospital  Toronto Ontario Canada"},{"name":"MAP Centre for Urban Health Solutions St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"MacPherson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Department of Medicine and School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abby","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases St. Michael's Hospital  Toronto Ontario Canada"},{"name":"MAP Centre for Urban Health Solutions St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Naccarato","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3069-2875","authenticated-orcid":false,"given":"Darrell H. S.","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases St. Michael's Hospital  Toronto Ontario Canada"},{"name":"MAP Centre for Urban Health Solutions St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12869"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010022\u201001120\u20107"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2368"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12755"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010013\u20100024\u20104"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010018\u20103319\u20104"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)31065\u20105"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540120050042891"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318158a44f"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01710\u201017"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002354"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002981"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(14)70847\u20103"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans\u2010BASHH\u20102023.101"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01902\u201020"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002633"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad404"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T15:41:06Z","timestamp":1743867666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,15]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/hiv.13759"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13759","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"type":"print","value":"1464-2662"},{"type":"electronic","value":"1468-1293"}],"subject":[],"published":{"date-parts":[[2025,1,15]]},"assertion":[{"value":"2024-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}