{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:27Z","timestamp":1787014287007,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hepatitis B surface antigen (HBsAg) loss is a rare event among persons with hepatitis B virus (HBV) monoinfection but seems to happen more frequently in people with HIV (PWH). We assessed the proportion of PWH\/HBV coinfection who experienced HBsAg loss during long\u2010term tenofovir\u2010therapy and evaluated its association with quantitative HBsAg (qHBsAg) levels at tenofovir start.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All Swiss HIV Cohort Study participants with two or more positive HBsAg measurements more than 6\u2009months apart, and at least 4\u2009years of tenofovir\u2010containing antiretroviral therapy (ART), were considered. Our main outcomes were the loss of HBsAg during the first 2\u2009years of tenofovir therapy and until the last available follow\u2010up. We explored the association between qHBsAg levels at tenofovir start and HBsAg loss using multivariable logistic regression adjusted for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 272 PWH and HBV coinfection were included. Median age was 41\u2009years (IQR 36\u201346) and 81% (221) were men. At tenofovir start, 62% (169\/272) received prior HBV active therapy, 49% (110\/224) were hepatitis B e antigen (HBeAg)\u2010positive, 82% (222\/272) had detectable HBV DNA (median 4.0 log10 IU\/mL, IQR 2.1\u20137.5) and 19% (46\/242) had low qHBsAg, defined as &lt;1000\u2009IU\/mL. HBsAg loss was observed in 7% (19\/272) of participants during the first 2\u2009years of tenofovir\u2010containing ART and in 16% (43\/272) after a median follow\u2010up time of 8.4\u2009years (IQR 2.6\u201315.8). At the last follow\u2010up, 59% (16\/27) of those with HBsAg loss had seroconverted for detectable anti\u2010HBs antibodies. In multivariable analyses, low qHBsAg at tenofovir start (OR 5.3, 95% CI 1.6\u201317.8) was a significant predictor of HBsAg loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found high rates of HBsAg loss in PWH and HBV coinfection on long\u2010term tenofovir\u2010containing ART, most of whom had low qHBsAg at tenofovir start.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.13766","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T04:24:09Z","timestamp":1740543849000},"page":"813-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Frequent hepatitis B surface antigen (\n                    <scp>HBsAg)<\/scp>\n                    clearance during tenofovir therapy in persons with\n                    <scp>HIV<\/scp>\n                    \/hepatitis B virus coinfection"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-5146","authenticated-orcid":false,"given":"Charles","family":"B\u00e9guelin","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Surial","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorin","family":"Begr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Munting","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huldrych F.","family":"G\u00fcnthard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology University Hospital Zurich  Zurich Switzerland"},{"name":"Institute of Medical Virology University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"St\u00f6ckle","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital Basel, University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enos","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Ente Ospedaliero Cantonale University of Geneva and University of Southern Switzerland  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Schmid","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Infection Prevention and Travel Medicine Cantonal Hospital of St. Gallen  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Calmy","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, HIV\/AIDS Unit Geneva University Hospital, University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Suter\u2010Riniker","sequence":"additional","affiliation":[{"name":"Institute for Infectious Diseases University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andri","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Wandeler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Institute of Social and Preventive Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Swiss HIV Cohort Study 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