{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:44:07Z","timestamp":1772988247706,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000864","name":"British HIV Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013842","name":"Imperial Health Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Human papillomavirus (HPV)\u2010associated cervical cancer risk is greater in people with HIV, although this has been at least partially attenuated by antiretroviral medication, enhanced cervical screening and HPV vaccination. People with perinatally acquired HIV may remain at higher risk due to lifelong immunosuppression and potentially reduced vaccine effectiveness. In this study in people with a cervix with perinatally acquired HIV, we explored cervical high\u2010risk HPV (hrHPV) prevalence and HPV serostatus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were recruited from a London HIV service between 2020 and 2022. Cervical samples from those sexually active were analysed for hrHPV (Cepheid GeneXpert) and cytology, and, if abnormal, a referral was made to colposcopy. Serum samples were tested for antibodies against HPV6\/11\/16\/18\/31\/33\/45\/52\/58. A self\u2010reported questionnaire including HPV vaccination history was completed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010seven people were recruited with a median age of 25\u2009years (range 18\u201334). Of those providing a cervical sample, 15\/47 (32%) were hrHPV\u2010positive and 12\/40 (30%) had abnormal cytology; 1\/17 referred for colposcopy had CIN2 (6%); 7\/15 (47%) with hrHPV were below the national screening age of 24.5\u2009years (range 19\u201323), and 9\/15 (60%) reported previous HPV vaccination. No vaccinated participants had hrHPV16\/18. Of those vaccinated, 37\/39 (95%) were seropositive for HPV16 and 30\/39 (77%) for HPV18. Two vaccinated participants were seronegative for HPV16\/18; both had detectable HIV viral loads and CD4 counts &lt;200 cells\/\u03bcL at recruitment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this small observational study we identified a 32% prevalence of cervical hrHPV. Cervical screening and HPV vaccination remain vital in this group, with further data required to inform screening guidelines for this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70001","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:36:40Z","timestamp":1741747000000},"page":"709-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High\u2010risk\n                    <scp>human papillomavirus<\/scp>\n                    prevalence and serostatus in a cohort of cisgender women and people with a cervix living with perinatally acquired\n                    <scp>HIV<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"given":"Merle","family":"Henderson","sequence":"first","affiliation":[{"name":"Imperial College London, Department of Infectious Disease Faculty of Medicine  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"},{"name":"NIHR Imperial Biomedical Research Centre (BRC)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dierdre","family":"Lyons","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Beddows","sequence":"additional","affiliation":[{"name":"Virus Reference Department, Public Health Microbiology Division UK Health Security Agency  London UK"},{"name":"Blood Safety, Hepatitis, STI and HIV Division UK Health Security Agency  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"Cowen","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Panwar","sequence":"additional","affiliation":[{"name":"Virus Reference Department, Public Health Microbiology Division UK Health Security Agency  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrina","family":"Wright","sequence":"additional","affiliation":[{"name":"Cervical Screening London Health Services Laboratories  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacquie","family":"Ujetz","sequence":"additional","affiliation":[{"name":"Imperial College London, Department of Infectious Disease Faculty of Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellie","family":"Crook","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasit","family":"Patel","sequence":"additional","affiliation":[{"name":"Cervical Screening London Health Services Laboratories  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Smith","sequence":"additional","affiliation":[{"name":"Cervical Screening London Health Services Laboratories  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8278-8564","authenticated-orcid":false,"given":"Caroline","family":"Foster","sequence":"additional","affiliation":[{"name":"Imperial College London, Department of Infectious Disease Faculty of Medicine  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Fidler","sequence":"additional","affiliation":[{"name":"Imperial College London, Department of Infectious Disease Faculty of Medicine  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"},{"name":"NIHR Imperial Biomedical Research Centre (BRC)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8232-9413","authenticated-orcid":false,"given":"Tamara","family":"Elliott","sequence":"additional","affiliation":[{"name":"Imperial College London, Department of Infectious Disease Faculty of Medicine  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"},{"name":"NIHR Imperial Biomedical Research Centre (BRC)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organisation.cervical cancer fact sheet [Internet].2024[cited 2024 Oct 9]. 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