{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:09:18Z","timestamp":1789092558195,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the association between biomarkers of inflammation, coagulation and immune activation and the incidence of non\u2010AIDS\u2010defining events in a contemporary, antiretroviral therapy (ART)\u2010experienced and virologically suppressed cohort of people living with HIV (PLWH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, observational cohort study. PLWH aged 30\u201370\u2009years, with undetectable HIV viral load and no history of cardiovascular disease, randomly selected from outpatients were included. At baseline, plasma biomarkers (high\u2010sensitivity C\u2010reactive protein [hs\u2010CRP], sCD163, sCD14, D\u2010dimer, interleukin\u20106, soluble vascular cell adhesion molecule [s\u2010VCAM] and lipoprotein\u2010associated phospholipase A2 [Lp\u2010PLA2] activity) were measured. Non\u2010AIDS\u2010defining events (non\u2010AIDS cancer and cardiovascular events) and non\u2010AIDS death were recorded until November 2022. Cumulative incidence was analysed for each endpoint and adjusted Cox regression used to assess associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 438 participants were included: 81.1% men, mean age 50.4 (SD 10.1) years. The median time on treatment was 15.5 (interquartile range [IQR] 8.69; 19.7) years and with undetectable viral load 7.05 (IQR 4.03; 11.6) years. A total of 77 non\u2010AIDS\u2010defining events were recorded in 70 patients (38 non\u2010AIDS cancers, 21 cardiovascular events, 37 non\u2010AIDS deaths) in a median follow\u2010up of 6.72\u2009(IQR 6.02; 7.36) years. The cumulative incidence for non\u2010AIDS cancer, cardiovascular event and non\u2010AIDS death was 8.7% (95% CI 6.2\u201311.7), 4.79% (95% CI 2.99\u20137.24) and 8.47% (95% CI 6\u201311.5), respectively. In adjusted models, sCD163 was associated with incident non\u2010AIDS cancer (hazard ratio [HR] 1.23, 95% CI 1.08\u20131.39), hs\u2010CRP with incident cardiovascular events (HR 1.61, 95% CI 1.05\u20132.47), sCD163 (HR 1.28, 95% CI 1.11\u20131.46) and D\u2010dimer (HR 1.75, 95% CI 1.08\u20132.86) with non\u2010AIDS death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Biomarkers of inflammation, monocyte activation and coagulation were associated with non\u2010AIDS\u2010defining events in a contemporary and long\u2010term suppressed cohort of PLWH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.70017","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T09:47:40Z","timestamp":1743068860000},"page":"849-857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biomarkers of inflammation and coagulation predict non\u2010<scp>AIDS<\/scp>\u2010defining events in a prospective cohort of virologically suppressed people living with <scp>HIV<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-1991","authenticated-orcid":false,"given":"Maria","family":"Saumoy","sequence":"first","affiliation":[{"name":"HIV and STD Unit, Department of Infectious Diseases Hospital Universitari de Bellvitge  L'Hospitalet de Llobregat Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL)  L'Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8518-1408","authenticated-orcid":false,"given":"Analuz","family":"Fernandez","sequence":"additional","affiliation":[{"name":"HIV and STD Unit, Department of Infectious Diseases Hospital Universitari de Bellvitge  L'Hospitalet de Llobregat Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL)  L'Hospitalet de Llobregat 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