{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:10:40Z","timestamp":1751429440667,"version":"3.41.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment adherence is extremely important for virological suppression and a good clinical outcome in HIV. People with good adherence to treatment are less likely to experience treatment failure and have a better clinical course of the infection. In this study, we aimed to elucidate the factors affecting treatment adherence in people with HIV in a single centre from Turkey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted at Tepecik Training and Research Hospital between September 2022 and December 2022. People with HIV over the age of 18\u2009years who had been on ART for at least 6\u2009months were included. Researchers designed a questionnaire by reviewing the literature to include factors that may affect treatment adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 306 people participated in the study (non\u2010response rate: 30%), of which 86% were male. Among the individual factors, feeling depressed (19.5%), treatment fatigue (18.5%), and anxiety about not being able to have a healthy child (18.2%) were prominent. Major HIV\/AIDS\u2010related factors were the presence of AIDS\u2010related opportunistic infection\/cancer\/comorbidity (20.9%) and lack of cure with current treatment (20.5%). Concern about side effects (14.6%) and drug\u2013drug interaction (13.6%) were the most frequently mentioned ART\u2010related factors. Main healthcare facility\u2010related barriers for adherence were insufficient counselling (15.2%) and inability to reach the HIV physician (15.1%). Only a few patients stated factors related to the health system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our study, the most significant factors affecting treatment adherence appeared to be individual and HIV\/AIDS\u2010related. It is important to be aware of these factors and to spend time on tailored counselling during initial diagnosis and follow\u2010up visits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.70042","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T11:04:31Z","timestamp":1746529471000},"page":"1150-1156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors affecting treatment adherence in people with HIV \u2013 A single\u2010Centre Descriptive Study from Turkey"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9076-428X","authenticated-orcid":false,"given":"Sabri","family":"Atalay","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Izmir Tepecik Education and Research Hospital University of HealthSciences  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-7918","authenticated-orcid":false,"given":"Kamil","family":"Mert","sequence":"additional","affiliation":[{"name":"Malazgirt Public Hospital  Mus Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Caglayan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ufuk","family":"Sonmez","sequence":"additional","affiliation":[{"name":"Bozyaka Training and Research Hospital, Infectious Diseases and Clinical Microbiology Clinic University of Health Sciences  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4840-6865","authenticated-orcid":false,"given":"Ilkay","family":"Akbulut","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Izmir Tepecik Education and Research Hospital University of HealthSciences  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"unstructured":"UNAIDS.Global HIV & AIDS statistics \u2014 Fact sheet. Global HIV statistics.https:\/\/www.unaids.org\/en\/resources\/fact-sheet(Accessed: 23 December 2024).","key":"e_1_2_12_2_1"},{"unstructured":"https:\/\/hsgm.saglik.gov.tr\/depo\/birimler\/bulasici\u2010hastaliklar\u2010ve\u2010erken\u2010uyari\u2010db\/Dokumanlar\/Istatistikler\/Ek_HIV\u2010AIDS_Istatistikleri.pdf(Accessed: 23 December 2024).","key":"e_1_2_12_3_1"},{"unstructured":"UNAIDS.Understanding measures of progress towards the 95\u201395\u201395 HIV testing treatment and viral suppression targets.https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/progress\u2010towards\u201095\u201095\u201095_en.pdf. (Accessed: March 4 2025).","key":"e_1_2_12_4_1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_5_1","DOI":"10.1126\/science.1228160"},{"doi-asserted-by":"publisher","key":"e_1_2_12_6_1","DOI":"10.1086\/427192"},{"unstructured":"E S. World Health Organization.Adherence to long\u2010term therapies: evidence for action.2003.https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/42682\/9241545992.pdf?sequence=1&isAllowed=y. 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