{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:08:14Z","timestamp":1789513694993,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019256","name":"NIHR Great Ormond Street Hospital Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, we explore changes in the demographic and clinical characteristics of pregnant people living with HIV, and their post\u2010partum HIV outcomes between 2000 and 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We described pregnancies resulting in a live birth from the linked UK CHIC\/ISOSS dataset in three calendar periods (2000\u20132006; 2007\u20132012; 2013\u20132018). Thereafter, we explored median CD4 count change and viral rebound from delivery to 12 months post\u2010partum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 4341 pregnancies were included. Maternal age increased from 31 (IQR: 28\u201335) years in 2000\u20132006 to 34 (IQR: 30\u201337) years in 2013\u20132018. Those conceiving in the most recent period had been diagnosed with HIV for longer (2000\u20132006: 3.0\u2009years to 2013\u20132018: 7.5\u2009years), had a higher median CD4 count (431\u2013583 cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ), and median nadir CD4 count (219\u2013260 cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ); they were also more likely to have initiated ART prior to estimated conception (70.1%\u201392.3%), and have a suppressed conception viral loads (VL) (56.6%\u201382.0%).\n                    <\/jats:p>\n                    <jats:p>\n                      There was no difference in median CD4 count change over the three calendar periods (2000\u20132006: +60 [IQR: \u221244, +179]; 2007\u20132012: +51 [\u221245, +172]; 2013\u20132018: +28 [\u2212100, +175] cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.12). The cumulative proportion of people with viral rebound at 12\u2009months post\u2010delivery was reduced in 2013\u20132018 (8.2%) when compared with previous periods (2000\u20132006: 28.1%; 2007\u20132012: 19.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinical management of pregnant people has changed over time, resulting in positive trends in this study both within pregnancy and post\u2010partum. Further work needs to understand what barriers remain for those who do not achieve optimal management of HIV in the post\u2010partum period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70056","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T06:49:20Z","timestamp":1749538160000},"page":"1304-1310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in characteristics and\n                    <scp>HIV<\/scp>\n                    \u2010clinical outcomes of pregnant people living with\n                    <scp>HIV<\/scp>\n                    in the\n                    <scp>UK<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-4914","authenticated-orcid":false,"given":"H.","family":"Okhai","sequence":"first","affiliation":[{"name":"Institute for Global Health University College London  London UK"},{"name":"National Institute for Health and Care Research (NIHR) Health Protection Research Unit (HPRU) in Blood\u2010borne and Sexually Transmitted Infections at University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Baskaran","sequence":"additional","affiliation":[{"name":"Institute for Global Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-1495","authenticated-orcid":false,"given":"L.","family":"Bukasa","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Peters","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-1956","authenticated-orcid":false,"given":"C.","family":"Thorne","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5173-2760","authenticated-orcid":false,"given":"C.","family":"Sabin","sequence":"additional","affiliation":[{"name":"Institute for Global Health University College London  London UK"},{"name":"National Institute for Health and Care Research (NIHR) Health Protection Research Unit (HPRU) in Blood\u2010borne and Sexually Transmitted Infections at University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the UK Collaborative HIV Cohort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw791"},{"key":"e_1_2_9_3_1","unstructured":"GOV.UK.ISOSS HIV report 2021.2021https:\/\/www.gov.uk\/government\/publications\/infectious\u2010diseases\u2010in\u2010pregnancy\u2010screening\u2010isoss\u2010hiv\u2010report\u20102021\/isoss\u2010hiv\u2010report\u20102021"},{"key":"e_1_2_9_4_1","unstructured":"GOV.UK.ISOSS HIV report 2022.2022https:\/\/www.gov.uk\/government\/publications\/infectious\u2010diseases\u2010in\u2010pregnancy\u2010screening\u2010isoss\u2010hiv\u2010report\u20102022\/isoss\u2010hiv\u2010report\u20102022"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2004.00197.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-110"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31823dbeac"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2011.554515"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-023-09536-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-015-0657-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(21)00194-6"},{"issue":"2","key":"e_1_2_9_12_1","first-page":"105","article-title":"Women empowerment through health information seeking: a qualitative 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