{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:38:15Z","timestamp":1787870295864,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Understanding preferences for long\u2010acting regimens (LAR) of people with HIV and health care professionals (HCPs) is important to optimize and personalize care. We identified preferences for current and future LAR among people with HIV and investigated HCPs\u2019 willingness to discuss these options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted during routine clinic visits at Amsterdam UMC between September 2023 and March 2024. Six hypothetical descriptions of LAR represented through vignettes, illustrating administration mode, frequency, location, administrator and side effects, were presented to people with HIV. We asked if people with HIV were willing to consider a switch to each of these vignettes or preferred to continue their current oral regimen. We asked HCPs if they would be likely to discuss each of the vignettes as potential treatment options with people with HIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 427 people with HIV [median age 56 (46\u201363) years; 79% males], 89% would be willing to switch to at least one and 10% to all options. The majority, namely, 76%, would consider switching to weekly tablets. Willingness to switch to intramuscular and subcutaneous injections, infusions and implants varied from 33% to 44%. HCPs (<jats:italic>n<\/jats:italic>\u2009=\u200923) indicated that they would discuss the different LAR options with 53% to 88% of people with HIV. All LAR options would be discussed in 32% of people with HIV. In 40%\u201343% of cases when people with HIV would be willing to switch to either intramuscular or intravenous regimes, the HCPs indicated that they would not discuss this treatment option.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most people with HIV would be willing to switch to weekly oral tablets. For the other LAR, lower levels of willingness were observed. Our findings suggest that HCPs may underestimate the willingness to switch to intramuscular injections and intravenous infusions in people with HIV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.70066","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T01:10:35Z","timestamp":1751505035000},"page":"1395-1404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mode of administration matters: Willingness of people with <scp>HIV<\/scp> to switch to future long\u2010acting treatments, and health care professionals' intention to discuss these options"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3565-2736","authenticated-orcid":false,"given":"Kyra F.","family":"Mendes de Leon","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Medical Psychology Amsterdam University Medical Center, Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Institute for Immunology &amp; Infectious Diseases Infectious Diseases Program  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health Research Institute Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Moody","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Institute for Immunology &amp; Infectious Diseases Infectious Diseases Program  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health Research Institute Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannine F.","family":"Nellen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Institute for Immunology &amp; Infectious Diseases Infectious Diseases Program  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"van Vugt","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Institute for Immunology &amp; Infectious Diseases Infectious Diseases Program  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Prins","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Institute for Immunology &amp; Infectious Diseases Infectious Diseases Program  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pythia T.","family":"Nieuwkerk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Medical Psychology Amsterdam University Medical Center, Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Institute for Immunology &amp; Infectious Diseases Infectious Diseases Program  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health Research Institute Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"van der Valk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Institute for Immunology &amp; Infectious Diseases Infectious Diseases Program  Amsterdam The Netherlands"},{"name":"Stichting HIV Monitoring  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103018(23)00028\u20100"},{"key":"e_1_2_13_3_1","volume-title":"The Path that Ends AIDS: UNAIDS Global AIDS Update 2023","author":"Joint United Nations Programme on HIV\/AIDS","year":"2023"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106220"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259582211009011"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002466"},{"key":"e_1_2_13_7_1","unstructured":"RanaAI BaoY ZhengL et al.Long\u2010acting injectable CAB\/RPV is superior to oral ART in PWH with adherence challenges: ACTG A5359. 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