{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:16:21Z","timestamp":1788380181771,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["22\u201015\u201000117"],"award-info":[{"award-number":["22\u201015\u201000117"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effectiveness of bictegravir (BIC)\u2010based antiretroviral therapy (ART) against HIV\u20101 sub\u2010subtype A6 viruses carrying the L74I polymorphic mutation in integrase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 100 ART\u2010naive people living with HIV from the Moscow Regional AIDS Center were enrolled between May and July 2023. HIV\u20101 subtypes and baseline drug resistance mutations were analysed prior to treatment initiation. All patients began a first\u2010line ART regimen and were followed for 40\u201348\u2009weeks, at which point viral load (VL) was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HIV\u20101 sub\u2010subtype A6 was identified in 78% of people living with HIV; among these, the L74I mutation was present in 97.3%. Of those carrying the mutation, only one patient experienced treatment failure, attributed to very low adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The BIC\/FTC\/TAF regimen is fully effective in treatment\u2010naive people living with HIV infected with HIV\u20101 sub\u2010subtype A6 harbouring the L74I integrase mutation. These findings support the continued use of second\u2010generation integrase strand transfer inhibitor (INSTI)\u2010based regimens for individuals with this HIV\u20101 subtype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70073","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T13:54:18Z","timestamp":1752069258000},"page":"1463-1467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010world efficacy of bictegravir\/emtricitabine\/tenofovir alafenamide regimen in patients infected with\n                    <scp>HIV<\/scp>\n                    \u20101 sub\u2010subtype\n                    <scp>A6<\/scp>\n                    harbouring the\n                    <scp>L74I<\/scp>\n                    mutation"],"prefix":"10.1111","volume":"26","author":[{"given":"Elena","family":"Orlova\u2010Morozova","sequence":"first","affiliation":[{"name":"Moscow Regional AIDS Center  Moscow Region Kotelniki Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Kireev","sequence":"additional","affiliation":[{"name":"Central Research Institute of Epidemiology  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Kirichenko","sequence":"additional","affiliation":[{"name":"Central Research Institute of Epidemiology  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyacheslav","family":"Bobkov","sequence":"additional","affiliation":[{"name":"Mechnikov Research Institute for Vaccines and Sera  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9180-9846","authenticated-orcid":false,"given":"Anastasiya","family":"Antonova","sequence":"additional","affiliation":[{"name":"Gamaleya National Research Center of Epidemiology and Microbiology  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8579-3274","authenticated-orcid":false,"given":"Rafael","family":"Yapparov","sequence":"additional","affiliation":[{"name":"Moscow Regional AIDS Center  Moscow Region Kotelniki Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5481-8957","authenticated-orcid":false,"given":"Marina","family":"Bobkova","sequence":"additional","affiliation":[{"name":"Moscow Regional AIDS Center  Moscow Region Kotelniki Russia"},{"name":"Mechnikov Research Institute for Vaccines and Sera  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"HIV Drug Resistance: Brief Report 2024","author":"World health organization","year":"2024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab297"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570162X15666170815162052"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12080838"},{"key":"e_1_2_11_6_1","first-page":"49","article-title":"RuSIDA: the online resource for the collection, storage and analysis of epidemiologicel, demographic and clinical laboratory data of patients","volume":"14","author":"Kuznetsova A","year":"2022","journal-title":"HIV Infect Immunosuppress Disord"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2013.04.032"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000216363.36786.2b"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku739"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2015.0095"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt474"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.5373"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz264"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037983"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002883"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13020205"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T10:44:59Z","timestamp":1756723499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/hiv.70073"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70073","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,8]]},"assertion":[{"value":"2025-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}