{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:22:46Z","timestamp":1784640166982,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>HIV diagnoses at 56 Dean Street (56DS), a sexual health clinic in London, UK, have continued to fall from 2017 to 2024. We describe the evolution of HIV prevention at 56DS from 2017 to 2024, its impact on new HIV from 2017 to 2024 and gaps in its provision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HIV tests, HIV diagnoses, numbers of individuals in HIV care and on antiretroviral therapy (ART), PrEP and PEPSE numbers from 1 January 2017 to 31 December 2024 were obtained from routine clinical coding. Characteristics of individuals diagnosed with HIV, including time to antiretroviral (ART), were obtained by notes review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The number of individuals newly diagnosed with HIV fell from 209 in 2017 to 82 in 2024, a decline of 61%. The quarterly number of HIV tests decreased from 21\u2009704 (Q1 2017) to around 15\u2009000 (Q1 2019). PrEP users increased from 170 (Q1 2017) and plateaued at 25\u2009149 (Q2 2023). 211 (19.5%) had ever used PrEP prior to their HIV diagnosis. Among individuals diagnosed with HIV, previous PrEP use rose from 9 (4.3%) in 2017 to 50 (61.0%) in 2024. Median time from confirmed HIV diagnosis to ART initiation was 7\u2009days (interquartile range 4\u201314) and has remained stable between 2017 and 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 56DS model of HIV combination prevention continues to work with HIV diagnoses in gay, bisexual and men who have sex with men falling over the last 8\u2009years, although the falls appear to be slowing in the last 3\u2009years. Strikingly, PrEP uptake has soared. We present gaps in prevention which pose the question: are we really going to get to zero HIV transmissions by 2030?<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70075","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:58:48Z","timestamp":1752731928000},"page":"1612-1618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>HIV<\/scp>\n                    prevention in London,\n                    <scp>UK<\/scp>\n                    , from 2017 to 2024: Outcomes, gaps and learnings"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-1281","authenticated-orcid":false,"given":"Gary","family":"Whitlock","sequence":"first","affiliation":[{"name":"Chelsea and Westminster Hospital  London UK"},{"name":"Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Cole","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshan","family":"Khurshid","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Boffito","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital  London UK"},{"name":"Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Suchak","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Dean Street Collaborative Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13149"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100263"},{"key":"e_1_2_8_4_1","unstructured":"HIV testing PrEP new HIV diagnoses and care outcomes for people accessing HIV services: 2024 report. UK Heath Security Agency UK Government. Accessed June 25 2025.https:\/\/www.gov.uk\/government\/statistics\/hiv\u2010annual\u2010data\u2010tables\/hiv\u2010testing\u2010prep\u2010new\u2010hiv\u2010diagnoses\u2010and\u2010care\u2010outcomes\u2010for\u2010people\u2010accessing\u2010hiv\u2010services\u20102024\u2010report"},{"key":"e_1_2_8_5_1","unstructured":"56 Dean Street webpage (dean.st). Accesssed June 25 2025.www.dean.st"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans\u20102020\u2010054943"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans\u20102022\u2010055558"},{"key":"e_1_2_8_8_1","unstructured":"Towards zero \u2013 an action plan towards ending HIV transmission AIDS and HIV\u2010related deaths in England \u2013 2022 to 2025. Department of Health & Social Care UK Government. Accessed February 25 2025.https:\/\/www.gov.uk\/government\/publications\/towards\u2010zero\u2010the\u2010hiv\u2010action\u2010plan\u2010for\u2010england\u20102022\u2010to\u20102025\/towards\u2010zero\u2010an\u2010action\u2010plan\u2010towards\u2010ending\u2010hiv\u2010transmission\u2010aids\u2010and\u2010hiv\u2010related\u2010deaths\u2010in\u2010england\u20102022\u2010to\u20102025"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12780"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans\u20102024\u2010056232"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103018(22)00364\u20102"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans\u20102020\u2010054732"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13310"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(21)00068-0"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70075","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:25:52Z","timestamp":1774329952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,16]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/hiv.70075"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70075","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,16]]},"assertion":[{"value":"2025-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}