{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:53:49Z","timestamp":1790816029512,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201026\/201.351\/2021"],"award-info":[{"award-number":["E\u201026\/201.351\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["445957\/2020\u20104"],"award-info":[{"award-number":["445957\/2020\u20104"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated liver disease (MASLD) might progress to cirrhosis. We aimed to evaluate the association of MASLD with the risk of developing clinically significant fibrosis (CSF) in people living with HIV (PLWH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PLWH have been followed up since 2015 in the PROSPEC\u2010HIV cohort (NCT02542020) with questionnaires, blood samples, and transient elastography (TE) on the same day. Participants with viral hepatitis, who were c\u2010ART na\u00efve, those with CSF at baseline or unreliable TE examinations and who lost follow\u2010up were excluded. Liver steatosis and fibrosis were assessed by TE\u2010Controlled Attenuation Parameter (CAP) and TE\u2010liver stiffness measurement (LSM), respectively. MASLD was defined as the presence of steatosis (CAP \u2265263\u2009dB\/m) at baseline with at least one cardiometabolic risk factor without hazardous alcohol intake [Alcohol Use Disorders Identification Test (AUDIT) score &lt;8]. The primary outcome was the development of CSF (LSM \u22658.0\u2009kPa) during follow\u2010up. Kaplan\u2013Meier curves and Cox proportional hazards multivariate models were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 304 participants with HIV mono\u2010infection under c\u2010ART and without liver fibrosis (43.4% male, median [interquartile range, IQR] age\u2009=\u200944 [IQR, 36\u201352] and body mass index [BMI]\u2009=\u200925.6 [23.0\u201329.0]\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and 17.8% with MASLD) were included. During a median follow\u2010up of 7.4 (IQR, 6.0\u20138.3)\u2009years, 11.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936) participants developed CSF. The cumulative incidence of CSF at the 8th year was higher in PLWH with MASLD than in those without (30.1% [95% CI, 18.0\u201347.6] vs. 8.8% [95% CI, 5.4\u201314.2],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). MASLD at baseline was significantly associated with the incidence of CSF in a multivariate Cox model (adjusted hazard ratio [aHR]\u2009=\u20092.92 [95% CI, 1.40\u20136.09]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MASLD increased the risk of liver fibrosis in people with HIV mono\u2010infection under c\u2010ART.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70079","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T13:30:28Z","timestamp":1753277428000},"page":"1525-1539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Metabolic dysfunction\u2010associated liver disease predicts incident liver fibrosis in people with\n                    <scp>HIV<\/scp>\n                    mono\u2010infection: A cohort study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7647-8943","authenticated-orcid":false,"given":"Juliana","family":"Fittipaldi","sequence":"first","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases (INI) Oswaldo Cruz Foundation (FIOCRUZ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5230-0003","authenticated-orcid":false,"given":"Sandra W.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases (INI) Oswaldo Cruz Foundation (FIOCRUZ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-8718","authenticated-orcid":false,"given":"Estev\u00e3o Portela","family":"Nunes","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases (INI) Oswaldo Cruz Foundation 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