{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:22:51Z","timestamp":1785223371292,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PCEFP3_181355"],"award-info":[{"award-number":["PCEFP3_181355"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["IZ07Z0_160876\/1"],"award-info":[{"award-number":["IZ07Z0_160876\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P500PM_221966"],"award-info":[{"award-number":["P500PM_221966"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011318","name":"Fondation Botnar","doi-asserted-by":"publisher","award":["REG\u201019\u2010008"],"award-info":[{"award-number":["REG\u201019\u2010008"]}],"id":[{"id":"10.13039\/501100011318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study describes the peripartum viral load (VL) monitoring cascade among individuals initiating antiretroviral therapy (ART) before delivery, as well as HIV testing, prophylaxis and outcomes of their infants in routine care in Lesotho, southern Africa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from medical charts review of paper\u2010based registers at 20 healthcare facilities in two districts of Lesotho were combined with data from the Viral Load Cohort North\u2010East Lesotho (VICONEL). We included people with HIV who attended their first antenatal care visit at a participating healthcare facility after 31 December 2019, had a delivery date before 1 January 2022 and initiated dolutegravir\u2010based ART before delivery, as well as their infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 353 pregnant people with HIV and 357 infants exposed to HIV were recorded. Among 17\/353 (5%) with an initial VL \u22651000 copies\/mL, a timely (within 4\u2009months) follow\u2010up VL was provided for 4\/17 (24%). Among 233\/353 (66%) with an initial VL &lt;1000 copies\/mL, a timely (within 7\u2009months) follow\u2010up VL was provided for 120\/233 (52%). For 103\/353 (29%), no VL measurement was available during pregnancy. Overall, peripartum VL monitoring was guideline\u2010adherent for 157\/353 (44%) pregnancies. Among infants exposed to HIV, 301\/357 (84%), 274\/357 (77%) and 172\/357 (48%) received guideline\u2010adherent prophylactic ART, early infant HIV testing within 2\u2009months and 9\u2010month HIV testing, respectively. Vertical transmissions occurred in 2\/357 (1%) infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There were substantial gaps in peripartum HIV service delivery or uptake as well as in HIV prevention and testing of infants exposed to HIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70082","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T07:01:07Z","timestamp":1753513267000},"page":"1540-1549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The peripartum viral load cascade and outcomes of infants exposed to\n                    <scp>HIV<\/scp>\n                    in Lesotho"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7771-8608","authenticated-orcid":false,"given":"Kathrin","family":"Haenggi","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Clinical Research University Hospital Basel  Basel Switzerland"},{"name":"University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moleboheng","family":"Mokebe","sequence":"additional","affiliation":[{"name":"SolidarMed, Partnerships for Health  Maseru Lesotho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipontso","family":"Motaboli","sequence":"additional","affiliation":[{"name":"SolidarMed, Partnerships for Health  Maseru Lesotho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makobefo G.","family":"Chakela","sequence":"additional","affiliation":[{"name":"SolidarMed, Partnerships for Health  Maseru Lesotho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mpho","family":"Kao","sequence":"additional","affiliation":[{"name":"SolidarMed, Partnerships for Health  Maseru Lesotho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathebe","family":"Kopo","sequence":"additional","affiliation":[{"name":"SolidarMed, Partnerships for Health  Maseru Lesotho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1051-5684","authenticated-orcid":false,"given":"Irene","family":"Ayakaka","sequence":"additional","affiliation":[{"name":"SolidarMed, Partnerships for Health  Maseru Lesotho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morongoe","family":"Nyakane","sequence":"additional","affiliation":[{"name":"Ministry of Health Lesotho  Maseru Lesotho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapiwa","family":"Tarumbiswa","sequence":"additional","affiliation":[{"name":"Ministry of Health Lesotho  Maseru Lesotho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3599-1791","authenticated-orcid":false,"given":"Niklaus D.","family":"Labhardt","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Clinical Research University Hospital Basel  Basel Switzerland"},{"name":"University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1874-6153","authenticated-orcid":false,"given":"Jennifer A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Clinical Research University Hospital Basel  Basel Switzerland"},{"name":"University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-9542","authenticated-orcid":false,"given":"Nadine","family":"Tschumi","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Clinical Research University Hospital Basel  Basel Switzerland"},{"name":"University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,26]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Joint United Nations Programme on HIV\/AIDS (UNAIDS).The path that ends AIDS: UNAIDS Global AIDS Update 2023 [Internet].2023.https:\/\/thepath.unaids.org\/wp-content\/themes\/unaids2023\/assets\/files\/2023_report.pdf"},{"key":"e_1_2_12_3_1","unstructured":"UNICEF DATA.HIV statistics \u2013 global and regional trends [Internet]. Accessed April 16 2025.https:\/\/data.unicef.org\/topic\/hivaids\/global-regional-trends\/"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.08.004"},{"key":"e_1_2_12_5_1","unstructured":"World Health Organisation.Consolidated guidelines on HIV prevention testing treatment service delivery and monitoring: recommendations for a public health approach [Internet].2021. Accessed July 19 2023.https:\/\/www.who.int\/publications-detail-redirect\/9789240031593"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.757400"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000881"},{"key":"e_1_2_12_8_1","unstructured":"2024 global AIDS report \u2014 the urgency of now: AIDS at a crossroads|UNAIDS [Internet]. Accessed April 3 2025.https:\/\/www.unaids.org\/en\/resources\/documents\/2024\/global\u2010aids\u2010update\u20102024"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01024-7"},{"key":"e_1_2_12_10_1","volume-title":"Guideline: Updates on HIV and Infant Feeding: The Duration of Breastfeeding, and Support from Health Services to Improve Feeding Practices Among Mothers Living with HIV [Internet]","author":"World Health Organization","year":"2016"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4393-5"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_12_13_1","unstructured":"Lesotho|UNAIDS.[Internet].2025. Accessed April 3 2025.https:\/\/www.unaids.org\/en\/regionscountries\/countries\/lesotho"},{"key":"e_1_2_12_14_1","unstructured":"The World Bank Group.World Bank open data.2023. Accessed July 20 2023.https:\/\/data.worldbank.org"},{"key":"e_1_2_12_15_1","unstructured":"Ministry of Health Government of Lesotho.National guidelines on the use of antiretroviral therapy for HIV prevention and treatment.2022."},{"key":"e_1_2_12_16_1","unstructured":"Ministry of Health Government of Lesotho.Addendum to the national guidelines on the use of antiretroviral therapy for HIV prevention and treatment.2019."},{"key":"e_1_2_12_17_1","unstructured":"Ministry of Health Government of Lesotho.National guidelines on the use of antiretroviral therapy for HIV Prevention and Treatment.2016."},{"key":"e_1_2_12_18_1","unstructured":"Ministry of Health Government of Lesotho.National Guidelines for the Elimination of Mother to Child transmission of HIV and syphilis.2020."},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-085404"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"issue":"3","key":"e_1_2_12_22_1","article-title":"The suboptimal pediatric HIV viral load Cascade: multidistrict cohort study among children taking antiretroviral therapy in Lesotho","volume":"41","author":"Muhairwe JA","year":"2022","journal-title":"Southern Africa Pediatr Infect Dis J"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220337"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-13504-2"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232358"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002457"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25376"},{"key":"e_1_2_12_28_1","unstructured":"World Health Organisation.Updated recommendations on HIV prevention infant diagnosis antiretroviral initiation and monitoring [Internet].2021. Accessed July 19 2023.https:\/\/iris.who.int\/bitstream\/handle\/10665\/340190\/9789240022232-eng.pdf?sequence=1"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000003295"},{"key":"e_1_2_12_30_1","unstructured":"Joint United Nations Programme on HIV\/AIDS (UNAIDS).Start free stay free AIDS free \u2013 final report on 2020 targets [Internet].2021.https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/2021_start-free-stay-free-aids-free-final-report-on-2020-targets_en.pdf"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/318530"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001552"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-200204150-00009"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(22)00289-2"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:25:38Z","timestamp":1774329938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,26]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/hiv.70082"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70082","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,26]]},"assertion":[{"value":"2024-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}