{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:58:59Z","timestamp":1774342739890,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["GLD21\/00052"],"award-info":[{"award-number":["GLD21\/00052"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>No data exists on responses to mRNA vaccines in kidney transplant recipients (KTRs) with HIV. We compared these responses in HIV\u2010positive (HIV+KTR+) and negative KTRs (HIV\u2010KTR+), and in people living with HIV (PLWH) without kidney transplantation (HIV+KTR\u2010).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In across\u2010sectional study of 33 patients receiving mRNA SARS\u2010CoV\u20102 vaccination, we evaluated the humoral response to mRNA SARS\u2010CoV\u20102 vaccination using a Luminex platform (IgG and IgM), and cellular response with specific T cell response (S\u2010and N\u2010 protein) by ELISpot. We used logistic regression models to assess associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study comprised 11 HIV\u2010KTR+, 11 HIV+KTR+, and 11 HIV+KTR\u2010. PLWH had suppressed viral load on ART. Seroconversion rates were 72.7% among KTRs, with no significant differences between HIV\u2010KTR+ (81.8%) and HIV+KTR+ (63.6%) (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.338). In HIV+KTR\u2010, seroconversion was 100%, higher than HIV+KTR+ (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.027). Cellular response against protein S occurred in 63.6% of cases, regardless of HIV, transplantation, or dose number. Higher age negatively influenced cellular response in HIV+KTR\u2010 (OR 0.77, 95%CI 0.60\u20100.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although cellular immune response was similar across all groups, humoral response was reduced in HIV+KTR+. In HIV+KTR\u2010, age reduced cellular response. These findings enhance our understanding of vaccine response in immunosuppressed populations and aid in optimizing vaccination strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70087","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T12:01:13Z","timestamp":1756123273000},"page":"1562-1573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cellular and humoral response after mRNA SARS\u2010CoV\u20102 vaccination in kidney transplant recipients living with HIV: A cross\u2010sectional study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0358-9370","authenticated-orcid":false,"given":"Judit","family":"Cacho","sequence":"first","affiliation":[{"name":"Renal Transplant Unit, Nephrology and Renal Transplantation Department Hospital Cl\u00ednic  Spain"},{"name":"Programa de Doctorat en Medicina i Recerca Translacional Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel K.","family":"Nomah","sequence":"additional","affiliation":[{"name":"Centre Estudis Epidemiol\u00f2gics sobre les Infeccions de Transmissi\u00f3 Sexual i Sida de Catalunya (CEEISCAT), Dept Salut Generalitat de Catalunya  Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Egri","sequence":"additional","affiliation":[{"name":"Department of Immunology, Centre de Diagn\u00f2stic Biom\u00e8dic Hospital Cl\u00ednic of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Cof\u00e1n","sequence":"additional","affiliation":[{"name":"Renal Transplant Unit, Nephrology and Renal Transplantation Department Hospital Cl\u00ednic  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Marcos","sequence":"additional","affiliation":[{"name":"Microbiology Department Hospital Clinic of Barcelona, ISGlobal, University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u2010Mar","family":"Mosquera","sequence":"additional","affiliation":[{"name":"Microbiology Department Hospital Clinic of Barcelona, ISGlobal, University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonsoles","family":"Sanchez\u2010Palomino","sequence":"additional","affiliation":[{"name":"CIBERINFEC. Instituto de Salud Carlos III  Madrid Spain"},{"name":"Infectious Diseases Service HIV Unit. Hospital Clinic\u2010Institut D'Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS), University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreu","family":"Bruguera","sequence":"additional","affiliation":[{"name":"Centre Estudis Epidemiol\u00f2gics sobre les Infeccions de Transmissi\u00f3 Sexual i Sida de Catalunya (CEEISCAT), Dept Salut Generalitat de Catalunya  Badalona Spain"},{"name":"CIBERESP. Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5066-6191","authenticated-orcid":false,"given":"Nuria","family":"Esforzado","sequence":"additional","affiliation":[{"name":"Renal Transplant Unit, Nephrology and Renal Transplantation Department Hospital Cl\u00ednic  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Bodro","sequence":"additional","affiliation":[{"name":"CIBERINFEC. Instituto de Salud Carlos III  Madrid Spain"},{"name":"Infectious Diseases Service HIV Unit. Hospital Clinic\u2010Institut D'Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS), University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Rovira","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service HIV Unit. Hospital Clinic\u2010Institut D'Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS), University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Hurtado","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service HIV Unit. Hospital Clinic\u2010Institut D'Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS), University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Vilella","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Epidemiology Department Hospital Cl\u00ednic\u2010Universitat de Barcelona\u2010ISGlobal  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz","family":"Diekmann","sequence":"additional","affiliation":[{"name":"Renal Transplant Unit, Nephrology and Renal Transplantation Department Hospital Cl\u00ednic  Spain"},{"name":"Laboratori Experimental de Nefrologia i Trasplantament (LENIT) Institut d'Investigaci\u00f3 Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asunci\u00f3n","family":"Moreno","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service HIV Unit. 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