{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:08Z","timestamp":1787014328462,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017784","name":"Gilead Research Scholars","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Monitoring transmitted drug resistance is crucial for guiding first\u2010line antiretroviral therapy (ART) and controlling the rising HIV epidemic in T\u00fcrkiye. This study aimed to determine the prevalence of transmitted antiretroviral resistance to protease inhibitors (PIs), nucleoside reverse transcriptase inhibitors (NRTIs), non\u2010nucleoside reverse transcriptase inhibitors (NNRTIs), integrase strand transfer inhibitors (INSTIs) and capsid assembly inhibitors (CAIs). We also assessed the distribution of HIV\u20101 subtypes and circulating recombinant forms (CRFs) at one of the main national referral centres in T\u00fcrkiye.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 104 consecutive ART\u2010na\u00efve people living with HIV who presented at Hacettepe University Hospital in Ankara between November 2021 and November 2022. Demographic data, probable transmission routes and geographic origins were recorded. HIV\u20101 genotyping was performed to identify subtypes and resistance\u2010associated mutations using standard methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 104 individuals, 97 were from 25 different cities in T\u00fcrkiye, while 7 originated from 5 different countries. The most probable transmission routes were men who have sex with men (MSM) (64.42%), heterosexual contact (30.77%) and unknown (4.81%). Resistance\u2010associated mutations were detected in 14.42% of individuals. Resistance rates were 1.92% for PI, 4.80% for NRTI and 7.69% for NNRTI. No resistance mutations were found against INSTI or CAI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transmitted resistance to PI, NRTI and NNRTI remains present in T\u00fcrkiye, though at moderate levels. The absence of resistance to INSTI and CAI supports their potential utility as effective components of treatment regimens in T\u00fcrkiye.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70109","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T04:57:36Z","timestamp":1757307456000},"page":"1739-1747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular epidemiological analysis and investigation of antiretroviral drug resistance profile, including capsid inhibitors, among treatment\u2010na\u00efve individuals with\n                    <scp>HIV<\/scp>\n                    \u20101 in T\u00fcrkiye"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9124-5182","authenticated-orcid":false,"given":"Adem","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology Mamak State Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fclin","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Kirsehir Research and Training Hospital  Kirsehir T\u00fcrkiye"},{"name":"Formerly National HIV\u2010AIDS and Viral Hepatitis Reference Laboratory, Reference Laboratories and Biological Products General Directorate of Public Health, Ministry of Health  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-4177","authenticated-orcid":false,"given":"Ceylan","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mertcan","family":"Uzun","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine 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\u00c7a\u011fkan","family":"\u0130nkaya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"P\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,7]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"The Urgency of Now: AIDS at a Crossroads","author":"UNAIDS","year":"2024"},{"key":"e_1_2_11_3_1","unstructured":"Republic Of T\u00fcrkiye Ministry of Health General Directorate of Public Health Department of Communicable Diseases and Early Warning.HIV\/AIDS Statistics 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