{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:44:12Z","timestamp":1785224652840,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010acting injectable cabotegravir and rilpivirine (LAI CAB\u2009+\u2009RPV) is an established maintenance strategy for people with HIV who are virologically suppressed, providing high efficacy and convenience in treatment. However, evidence in older adults (\u226560\u2009years), a growing and complex population, is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an ambispective real\u2010world sub\u2010analysis of the Spanish RELATIVITY cohort, including people with HIV aged \u226560\u2009years who initiated LAI CAB\u2009+\u2009RPV across 58 centres. Outcomes (virological suppression, safety, discontinuation and adherence) were compared with those &lt;60\u2009years of age using Kaplan\u2013Meier and Cox models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 3146 participants, 370 (11.8%) were aged \u226560\u2009years (median age 63.0 [61.0, 67.0]; 78.3% male). Older adults had longer ART exposure (median 18.0 [11.0, 25.0] years), more comorbidities (79.5%) and lower historical CD4 nadirs than younger adults. After 15\u2009months of follow\u2010up, the rates of virological suppression remained high and comparable between the groups (97.3% in those aged \u226560\u2009years vs. 96.8% in those &lt;60\u2009years), with very low protocol\u2010defined virological failure rates (0.3% vs. 0.7%). Discontinuations (7.8% vs. 6.1%) and adverse events (1.6% vs. 0.8%) were infrequent and showed no significant differences between age groups. Adherence to injection visits was excellent, with &gt;89% of the participants aged \u226560\u2009years demonstrating perfect adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large multicentre real\u2010world sub\u2010study, LAI CAB\u2009+\u2009RPV maintained virological control and showed good tolerability in older people with HIV despite high multi\u2010morbidity and long\u2010term ART exposure. These findings extend the evidence from previous trials and support LAI CAB\u2009+\u2009RPV as a feasible option for geriatric HIV care. Longer follow\u2010up will provide further insights into durability and quality\u2010of\u2010life benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70114","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:27:45Z","timestamp":1761071265000},"page":"58-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical outcomes of long\u2010acting cabotegravir and rilpivirine in people with\n                    <scp>HIV<\/scp>\n                    aged 60 and older: Real\u2010world data from the Spanish\n                    <scp>RELATIVITY<\/scp>\n                    cohort"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-114X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Troya","sequence":"first","affiliation":[{"name":"Hospital Universitario Infanta Leonor  Madrid 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Canarias  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Son Ll\u00e1tzer  Palma Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Crussels","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Lozano Blesa  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Torralba","sequence":"additional","affiliation":[{"name":"Hospital Universitario Guadalajara  Guadalajara Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-5728","authenticated-orcid":false,"given":"Carmen","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de las Nieves  Granada 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