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In Part I, Version 13.0 recommends the following first\u2010line regimens for adults with HIV\u20101: tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide (TAF) with either lamivudine or emtricitabine (XTC), in combination with dolutegravir (DTG), bictegravir (BIC), or doravirine (DOR); or a dual therapy option consisting of XTC plus DTG. Version 13.0 introduces a completely new section on HIV\u20102. The preferred first\u2010line regimens for HIV\u20102 include triple therapy with a second\u2010generation integrase inhibitor: either TAF\/FTC\/BIC or TDF\/XTC\u2009+\u2009DTG. The PrEP section has been updated to include the use of long\u2010acting injectable antiretrovirals. Drug\u2013drug interaction (DDI) tables have been updated to include long\u2010acting antiretrovirals and considerations related to substance use, including drugs used to enhance or prolong sexual activity (chemsex). Tables for preferred and alternative ART regimens in children and adolescents have been updated, with particular attention to neonates. A new section on transition to adult care has also been included. The co\u2010infections section has undergone extensive revision, especially regarding HBV, sexually transmitted infections, opportunistic infections (particularly tuberculosis, leishmaniasis, and cryptococcosis) and mpox, incorporating recent clinical trial data on tecovirimat. In Part II, Version 13.0 introduces major updates to the comorbidities section. In the cancer section, screening recommendations for anal and breast cancer have been updated. Cardiovascular and metabolic health sections have been significantly modified, reflecting recent advances and the use of statins in people with HIV. Topics such as kidney and liver complications, mental health, travel and solid organ transplantation have been thoroughly revised. New sections on sleep health and a unified substance use section have been added.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In 2025, the EACS Guidelines underwent a comprehensive update and restructuring. They now consist of two distinct parts and include several new sections. The recommendations are available as a free mobile app and in an interactive web format.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70120","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T07:30:09Z","timestamp":1760513409000},"page":"18-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Major revision version 13.0 of the European\n                    <scp>AIDS<\/scp>\n                    Clinical Society guidelines 2025"],"prefix":"10.1111","volume":"27","author":[{"given":"Juan","family":"Ambrosioni","sequence":"first","affiliation":[{"name":"HIV Unit, Infectious Diseases Service Hospital Clinic\u2010Fundacio de recerca Clinic Barcelona \u2013 Institut de investigacions Biomediques August Pi i Sunyer  Barcelona Spain"},{"name":"CIBERINFEC Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura 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