{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:11:54Z","timestamp":1790140314876,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100024710","name":"ASHM Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop Australian anal cancer screening guidelines for people living with HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 2023, ASHM Health assembled a committee to create guidelines, based on existing international guidelines and utilizing data from the Study of the Prevention of Anal Cancer (SPANC). SPANC provided Australian\u2010specific data on different screening methodologies for the detection of anal high\u2010grade squamous intraepithelial lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The guidelines were released in March 2025. They recommend primary high\u2010risk human papillomavirus (HRHPV) testing with cytology triage for high\u2010resolution anoscopy. Gay, bisexual and other men who have sex with men (GBM) and trans\u2010women living with HIV should be offered screening from 35\u2009years of age. Cis\u2010women, trans\u2010men and other cis\u2010men (not GBM) living with HIV should be offered screening from 45\u2009years of age. All anal cancer screening should include annual digital ano\u2010rectal examination, examination of the peri\u2010anal region and a thorough medical history. Screening should be repeated every 3\u2009years for those who screen negative.<\/jats:p>\n                    <jats:p>Screening should be discontinued, with shared decision\u2010making, at age 75\u2009years and\/or in individuals with two consecutive negative screening visits who are not currently sexually active.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These are the first guidelines to recommend primary HRHPV testing with cytology triage as the screening modality. They will assist clinicians in identifying and screening people living with HIV at higher risk of anal cancer and will enable screening and referral of people living with HIV at highest risk for high\u2010resolution anoscopy, while screening and treatment services capacity are expanded in Australia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70133","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:04:14Z","timestamp":1761264254000},"page":"1930-1938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Australian guidelines for anal cancer screening using anal human papillomavirus testing with cytology triage in people living with\n                    <scp>HIV<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-3769","authenticated-orcid":false,"given":"I. 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