{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:58:18Z","timestamp":1773413898165,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023812","name":"St Vincent's Curran Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People living with HIV are at the highest risk of anal cancer. Screening people living with HIV and treatment of identified anal high\u2010grade squamous intraepithelial lesions (HSIL) are now recommended to reduce cancer incidence. We investigated the implementation of such a programme in a large HIV clinic in Sydney, Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Men who have sex with men (MSM) living with HIV aged 35+ were invited to participate in an anal screening programme. Following informed consent, participants underwent digital anorectal examination (DARE) and anal swabs (self\u2010 and clinician\u2010collected) for HPV genotyping and cytological testing. Swab collection order was randomized. Positive results for HPV16, atypical squamous cells\u2014cannot exclude HSIL (ASC\u2010H), HSIL or abnormal DARE suspicious of anal cancer led to immediate referral for high\u2010resolution anoscopy (HRA). The rest returned in 6\u2009months for repeat tests. Screening logs captured reasons for declining screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 225 people invited to participate, 23.1% declined, 49.8% did not respond to repeated contact and 27.1% consented (median age 57.5\u2009years). Of those who consented, 66.1% had high\u2010risk HPV and 78.7% had cytological abnormalities of which 48.6% were HSIL or ASC\u2010H. No differences in swab positivity were found between self\u2010 and clinician\u2010collected specimens. Thirty\u2010eight participants were referred for HRA with 100% attendance. Of these, 42.1% had histological HSIL. One had anal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Uptake of the screening programme was poor, with only a quarter agreeing to participate. Those who underwent screening had excellent adherence (100% HRA attendance) with substantial quantities of HSIL found. Further research is required to understand and address barriers to initial screening programme uptake.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70151","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:45:19Z","timestamp":1763466319000},"page":"351-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anal cancer screening in men who have sex with men living with\n                    <scp>HIV<\/scp>\n                    : The pilot of anal screening study (\n                    <scp>PASS<\/scp>\n                    )"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6950-4029","authenticated-orcid":false,"given":"Clare E. F.","family":"Dyer","sequence":"first","affiliation":[{"name":"Kirby Institute University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8573-637X","authenticated-orcid":false,"given":"Fengyi","family":"Jin","sequence":"additional","affiliation":[{"name":"Kirby Institute University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-8617","authenticated-orcid":false,"given":"Jennifer M.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Douglass Hanly Moir Pathology  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-3769","authenticated-orcid":false,"given":"I. Mary","family":"Poynten","sequence":"additional","affiliation":[{"name":"Kirby Institute University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2613-6910","authenticated-orcid":false,"given":"Philip H.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"NSW State Reference Laboratory for HIV, St Vincent's Centre for Applied Medical Research St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Carr","sequence":"additional","affiliation":[{"name":"Immunology &amp; HIV St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1048-6396","authenticated-orcid":false,"given":"Gail V.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Infectious Diseases St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-1032","authenticated-orcid":false,"given":"Andrew E.","family":"Grulich","sequence":"additional","affiliation":[{"name":"Kirby Institute University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1859-0761","authenticated-orcid":false,"given":"Richard J.","family":"Hillman","sequence":"additional","affiliation":[{"name":"Kirby Institute University of New South Wales  Sydney New South Wales Australia"},{"name":"Dysplasia and Anal Cancer Services St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33185"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv086"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24116"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2201048"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34850"},{"key":"e_1_2_8_7_1","unstructured":"U.S. Department of Health and Human Services (HHS) and the National Institutes of Health (NIH).Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV: Recommendations for Anal Cancer Screening for People With HIV 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