{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:32:29Z","timestamp":1791952349976,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare HIV diagnosis pathways, baseline clinical characteristics and treatment outcomes among cis\u2010gender and trans\u2010gender women newly diagnosed with HIV at two European centres\u2014Padua University Hospital (Italy) and 56 Dean Street, Chelsea and Westminster Hospital (London, UK).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective observational study was conducted including cis\u2010gender and trans\u2010gender women diagnosed with HIV between 2017 and 2024. Demographic, clinical and virological parameters were collected at baseline and during follow\u2010up. Outcomes included baseline CD4 count, HIV\u2010RNA, antiretroviral therapy (ART) regimen, time to ART initiation and time to viral suppression (&lt;200\u2009copies\/mL). Comparisons were made by gender identity and by clinical centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 115 women were included (74 cis\u2010gender, 41 trans\u2010gender). Trans\u2010gender women were older and more frequently of non\u2010European origin. First\u2010time HIV testing was significantly more common in Padua, where both cis\u2010 and trans\u2010gender women presented with lower CD4 counts and higher HIV\u2010RNA, indicating later diagnosis compared with London. Prior engagement with HIV prevention (PrEP\/PEP and routine screening) was more frequent at 56 Dean Street. Despite baseline differences, ART regimens\u2014predominantly integrase inhibitor\u2013based\u2014were similar across centres. Time to ART initiation and time to viral suppression did not differ significantly between groups or settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cis\u2010 and trans\u2010gender women face persistent disparities in HIV diagnosis across European healthcare settings. Later presentation was more common in Padua, reflecting gaps in screening and prevention coverage. Once linked to care, treatment outcomes were similar. Strengthening gender\u2010affirming, context\u2010specific HIV testing and prevention strategies is essential to reduce diagnostic inequities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70160","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T03:19:39Z","timestamp":1766373579000},"page":"316-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>HIV<\/scp>\n                    diagnosis and treatment outcomes in cis\u2010 and trans\u2010gender women across two European centres: A comparative observational study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0263-0703","authenticated-orcid":false,"given":"Maria","family":"Mazzitelli","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Unit Padua University Hospital  Padua Italy"},{"name":"Department of Medical and Surgical Sciences Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peacchaima","family":"Purusothman","sequence":"additional","affiliation":[{"name":"Hospital Tengku Ampuan Rahimah  Klang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrezia","family":"Calandrino","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Suchak","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Mengato","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy Unit Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Scaglione","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Cattelan","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2213-1103","authenticated-orcid":false,"given":"Marta","family":"Boffito","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital Foundation Trust  London UK"},{"name":"Imperial College of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-1281","authenticated-orcid":false,"given":"Gary","family":"Whitlock","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70315-8"},{"key":"e_1_2_9_3_1","article-title":"Time from human immunodeficiency virus seroconversion to reaching CD4+ cell count thresholds","volume":"13","author":"Lodi S","year":"2013","journal-title":"BMC Infect Dis"},{"issue":"3","key":"e_1_2_9_4_1","article-title":"Intersectional stigma and HIV\u2010related outcomes among key populations","volume":"24","author":"Logie CH","year":"2021","journal-title":"J Int AIDS Soc"},{"issue":"10042","key":"e_1_2_9_5_1","first-page":"412","article-title":"HIV epidemics among transgender women","volume":"388","author":"Poteat T","year":"2016","journal-title":"Lancet"},{"key":"e_1_2_9_6_1","unstructured":"Istituto Superiore di Sanit\u00e0 (ISS).Notiziario ISS \u2013 HIV\/AIDS in Italia 2022."},{"key":"e_1_2_9_7_1","unstructured":"European Centre for Disease Prevention and Control (ECDC).HIV\/AIDS Surveillance in Europe 2023\u20132022 data."},{"key":"e_1_2_9_8_1","unstructured":"European AIDS Clinical Society (EACS).Guidelines version 12.0 October 2023."},{"key":"e_1_2_9_9_1","unstructured":"World Health Organization.Consolidated guidelines on HIV prevention diagnosis treatment and care for key populations.2022."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2019.0013"},{"issue":"9","key":"e_1_2_9_11_1","first-page":"e606","article-title":"Outcomes of HIV treatment and care in the UK: 20\u2009years of data","volume":"6","author":"Croxford SE","year":"2021","journal-title":"Lancet Public Health"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T13:25:35Z","timestamp":1769952335000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,21]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/hiv.70160"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70160","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,21]]},"assertion":[{"value":"2025-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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