{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:03Z","timestamp":1787014323049,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001117","name":"amfAR, The Foundation for AIDS Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001117","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate real\u2010world outcomes of dolutegravir (DTG)\u2010based first\u2010line antiretroviral therapy (ART) among people with HIV in Thailand, where baseline HIV\u20101 RNA and resistance testing is not routinely available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study enrolled ART\u2010naive Thai people with HIV aged \u226515\u2009years who initiated DTG\u2010based ART between 2020 and 2023 under the national Universal Health Coverage programme. People with HIV with \u22651 post\u2010baseline HIV viral load (VL) measurement were included. Virological non\u2010suppression (VNS) was defined as VL \u22651000 copies\/mL after \u22656\u2009months of ART. The primary outcome was the proportion achieving virological suppression (VL &lt;50 copies\/mL). Competing\u2010risk regression was used to identify factors associated with VNS, accounting for death and loss to follow\u2010up (LTFU). Mortality data were confirmed via the national death registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 10\u2009475 people with HIV initiating DTG\u2010based ART, 84.5% achieved virological suppression and 95.3% achieved VL\u2009&lt;\u2009200 copies\/mL within 1\u2009year. The cumulative VNS incidence was 10.1% (95% confidence interval [CI]: 9.6%\u201310.5%), and highest among those with late ART initiation (10.6% [95% CI: 7.4%\u201314.3%]). VNS was significantly associated with younger age, 15\u201324\u2009years (aSHR 2.28, 95% CI:1.66\u20133.12), 25\u201334\u2009years (aSHR1.43, 95% CI:1.07\u20131.90), baseline CD4\u2009&lt;\u2009100 cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      (aSHR 2.11, 95% CI: 1.36\u20133.27) and residence in northern (aSHR 1.64, 95% CI: 1.12\u20132.40) or southern Thailand (aSHR 1.99, 95%: 1.30\u20133.04). Same\u2010day\/rapid ART initiation, sex and WHO HIV clinical staging were not associated with VNS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nationwide rollout of DTG\u2010based ART achieved excellent virological outcomes in Thailand. However, higher VNS risk among adolescents, individuals with advanced HIV disease and those in specific regions underscores the need for targeted interventions to improve treatment equity and long\u2010term viral suppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70178","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T04:38:18Z","timestamp":1766205498000},"page":"459-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and predictors of virological non\u2010suppression in Thailand's rollout of dolutegravir\u2010based first\u2010line antiretroviral therapy: A nationwide cohort analysis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4292-1797","authenticated-orcid":false,"given":"Napon","family":"Hiranburana","sequence":"first","affiliation":[{"name":"HIVNAT, Thai Red Cross AIDS and Infectious Diseases Research Centre  Bangkok Thailand"},{"name":"Center of Excellence in Tuberculosis, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0913-1723","authenticated-orcid":false,"given":"Jiratchaya","family":"Sophonphan","sequence":"additional","affiliation":[{"name":"HIVNAT, Thai Red Cross AIDS and Infectious Diseases Research Centre  Bangkok Thailand"},{"name":"Research Affairs, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1919-4525","authenticated-orcid":false,"given":"Stephen J.","family":"Kerr","sequence":"additional","affiliation":[{"name":"HIVNAT, Thai Red Cross AIDS and Infectious Diseases Research Centre  Bangkok Thailand"},{"name":"Research Affairs, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"The Kirby Institute University of New 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