{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:57:33Z","timestamp":1773413853641,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>HIV pre\u2010exposure prophylaxis (PrEP) access still appears to be disproportionate, with existing barriers. This study aims to describe the characteristics, retention and feasibility of TelePrEP, Italy's first remote PrEP service, which was launched in February 2023 to address inequities in PrEP access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TelePrEP provides online PrEP counselling, prescriptions and follow\u2010ups via community healthcare workers and infectious disease physicians, targeting individuals unable to attend in\u2010person services in existing local services. Between February 2023 and April 2025, all enrolled clients underwent baseline risk assessment, laboratory testing at local facilities, remote clinical evaluation and follow\u2010up every 3\u2009months. Descriptive statistics analysed demographics, retention and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 434 individuals who sought information about PrEP, 187 (43.1%) enrolled in TelePrEP, while 93 (21.4%) were directly referred to existing local PrEP services. The majority were assigned male at birth (97.3%), were identified as MSM (75.9%) and were 29\u201340\u2009years old (43.9%). Of these, 57.2% held a university degree, and two\u2010thirds (66.8%) lived in rural areas or small towns. The most common reasons for choosing TelePrEP were convenience and safety: 22.9% cited long hospital waiting times and 27.8% cited distance. Follow\u2010up visits were completed by 104 individuals (55.6%), of whom 43.3% took daily oral PrEP and 52.9% on\u2010demand. No HIV infections were recorded during the follow\u2010up period. Of the 115 clients who discontinued the programme, 44 were linked to local PrEP services after starting PrEP remotely. Overall satisfaction was high, with 92.3% agreeing that PrEP improved their sexual well\u2010being.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TelePrEP is a feasible, acceptable model overcoming systemic barriers to PrEP access in Italy, effectively reaching underserved populations, with no evidence of breakthrough HIV infections. Integration into national HIV strategies might improve equity and reduce healthcare burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70179","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:10:19Z","timestamp":1765264219000},"page":"485-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>TelePrEP<\/scp>\n                    in Italy: A remote service to expand equitable access to\n                    <scp>HIV<\/scp>\n                    pre\u2010exposure prophylaxis"],"prefix":"10.1111","volume":"27","author":[{"given":"Maria Luisa","family":"Cosmaro","sequence":"first","affiliation":[{"name":"Fondazione LILA Milano ETS  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Penon","sequence":"additional","affiliation":[{"name":"Fondazione LILA Milano ETS  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Falzetta","sequence":"additional","affiliation":[{"name":"Fondazione LILA Milano ETS  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Candela","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo Roberto","family":"Raccagni","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Nozza","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"Infectious Diseases Unit, IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","unstructured":"MazzottaV TavelliA MasoeroT et al.Comparison of users accessing PrEP in hospital\u2010based or community\u2010based settings: first picture from the PrIDE cohort (OC72) 17th Italian Conference on AIDS and Antiviral Research (ICAR). Padua 21st\u201023rd May 2025.","DOI":"10.1136\/sextrans-ICAR-2025.64"},{"key":"e_1_2_11_3_1","unstructured":"NozzaS MasoeroT TavelliA et al.Implementation of PrEP in Italy: Highlights and Challenges. Findings from the PrIDE Survey (P125) 17th Italian Conference on AIDS and Antiviral Research (ICAR). Padua 21st\u201023rd May 2025."},{"issue":"1","key":"e_1_2_11_4_1","first-page":"37","article-title":"Brief Report: Gaps in HIV Preexposure Prophylaxis Acceptance: Findings From an Outpatient HIV Testing Service in Italy","volume":"98","author":"Raccagni AR","year":"2025","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-025-04736-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000003610"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-024-04366-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003601"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2196\/67445"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","DOI":"10.1177\/15248399251347253","article-title":"Facilitators and Barriers to Equitable Implementation of Telehealth PrEP Delivery: A Qualitative Descriptive Study of Program Staff and Stakeholders","author":"Bonett S","year":"2025","journal-title":"Health Promot Pract"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jeph.2024.202201"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","DOI":"10.1177\/20552076231217816","article-title":"Delivering HIV prevention medication online: Findings from a qualitative study exploring the acceptability of an online HIV pre\u2010exposure prophylaxis (PrEP) care pathway among service users and healthcare professionals","volume":"9","author":"Kincaid R","year":"2023","journal-title":"Digit Health"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318256b2f6"},{"key":"e_1_2_11_14_1","unstructured":"Centers for Disease Control and Prevention (CDC).PrEP guidelines.https:\/\/www.cdc.gov\/hivnexus\/hcp\/prep\/index.html(accessed: 12th August 2025)."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaf539"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-024-02862-0"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000003664"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.26468"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T10:55:51Z","timestamp":1773399351000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/hiv.70179"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70179","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"2025-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}