{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T05:58:28Z","timestamp":1775455108947,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Literature on vulvar cancer (VC) and vulvar intraepithelial neoplasia (VIN) in women living with HIV (WLWH) is scarce with no data on human papillomavirus (HPV) genotyping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared disease characteristics and HPV genotyping on biopsies from WLWH and HIV\u2010negative women (HNW) followed for VIN2+ (VIN2\/3 and VC) at Saint\u2010Pierre Hospital between 2000 and 2022.<\/jats:p>\n                    <jats:p>Then, a case control study identified VIN2+ risk factors among WLWH with VIN2+ (cases) and WLWH without VIN followed at the same period (controls), matched for age, ethnicity, and HIV follow\u2010up duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to 65 HNW (28 VC\/37 VIN), 25 WLWH (4 VC\/21 VIN) were younger at time of VIN2+ diagnosis (48 vs. 58.7\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), had more frequently cervical or anal (multicentric) dysplasia (52% vs. 22%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and non\u2010excisional treatments, and less often healthy margins in excisions (14% vs. 43%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). In WLWH, high\u2010risk HPV was found in 100% (vs. 85% in HNW) with more multiple genotype infections (40% vs. 13%); HPV16 was found in 80% of VC and 73% of VIN in WLWH versus 91% and 79% in HNW. Compared to 75 controls, 25 cases had significantly more frequently prior cervical high\u2010grade intraepithelial lesion (HSIL) (40%), lower median CD4\u2010lymphocyte count (382\/\u03bcL), and shorter duration of undetectable HIV viremia (4.8\u2009years) than controls (respectively 0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001; 770 CD4\/\u03bcL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021; 10.6\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>WLWH develop VIN2+ younger than HNW, with more multiple HPV infections but less HPV 16, more multicentric lesions, and less excisions with negative margins. Risk factors for developing VIN2+ in WLWH include lack of viremia control and immunosuppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70184","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:04:55Z","timestamp":1767150295000},"page":"560-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors, management, and\n                    <scp>HPV<\/scp>\n                    genotyping of vulvar intraepithelial neoplasia (\n                    <scp>VIN<\/scp>\n                    ) in women living with\n                    <scp>HIV<\/scp>\n                    : A comparison with women without\n                    <scp>HIV<\/scp>\n                    and a case control study"],"prefix":"10.1111","volume":"27","author":[{"given":"Elise","family":"Baucher","sequence":"first","affiliation":[{"name":"Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Gilles","sequence":"additional","affiliation":[{"name":"Gynecology Department Saint\u2010Pierre University Hospital  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Manigart","sequence":"additional","affiliation":[{"name":"Gynecology Department Saint\u2010Pierre University Hospital  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Barlow","sequence":"additional","affiliation":[{"name":"Gynecology Department Saint\u2010Pierre University Hospital  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"De Wind","sequence":"additional","affiliation":[{"name":"Pathology laboratory University Hospital of Brussels, Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davy","family":"Vanden Broeck","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pathology AML Sonic Healthcare Belgium and Belgian National Reference Laboratory for HPV  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Delforge","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department and HIV Reference Centre Saint\u2010Pierre University Hospital Brussels  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Martin","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department and HIV Reference Centre Saint\u2010Pierre University Hospital Brussels  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-9289","authenticated-orcid":false,"given":"Deborah","family":"Konopnicki","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department and HIV Reference Centre Saint\u2010Pierre University Hospital Brussels  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.02.012"},{"key":"e_1_2_8_3_1","unstructured":"Global Cancer Observatory.Accessed August 9 2025.2022https:\/\/gco.iarc.who.int\/today\/en\/dataviz\/maps-heatmap?cancers=21&types=0&sexes=0&palette=Blues&mode=population"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2016.02.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.2120"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33198"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30821"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.23274"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30459-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy1123"},{"issue":"3","key":"e_1_2_8_11_1","first-page":"425","article-title":"High\u2010risk human papillomavirus genotypes distribution in a cohort of HIV\u2010positive women living in Europe: epidemiological implication for vaccination against human papillomavirus","volume":"30","author":"Konopnicki D","year":"2016","journal-title":"AIDS"},{"key":"e_1_2_8_12_1","unstructured":"European AIDS Clinical Society Guidelines.Immunisation in Persons with HIV. 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