{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:16:49Z","timestamp":1777972609913,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biktarvy is a single\u2010tablet anti\u2010retroviral regimen composed of a second\u2010generation integrase\u2010inhibitor (Bictegravir), in combination with tenofovir alafenamide and emtricitabine. Biktarvy has been shown to be highly effective in achieving and sustaining viral suppression. However, several studies have highlighted altered glycaemic control in individuals switching to Biktarvy from other regimens. The aim of this study was to quantify glucose disposal rates (GDR) in HIV\u2010seronegative healthy volunteers following the administration of Biktarvy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A 72\u2009day, open\u2010label, two\u2010arm, crossover, single\u2010centre study. Participants were randomized 1:1 to either start 28\u2009days of Biktarvy followed by 44\u2009days without treatment (Group 1), or no treatment for 43\u2009days followed by Biktarvy treatment for 28\u2009days (Group 2). A hyper\u2010insulinaemic\u2010euglycaemic clamp was carried out at days 1, 28 and 72 with a 14\u2010day washout period following the second clamp. Statistical assessments of change in estimated GDR were carried out using Wilcoxon signed\u2010rank test (within\u2010group) and Two\u2010sample Wilcoxon rank\u2010sum (Mann\u2013Whitney) test (between\u2010group). The primary study outcome was change from baseline in total body glucose disposal by euglycaemic clamp method following 28\u2009days treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 18 volunteers completed the study, with 11 in group 1 and seven in group 2. Within Group 1 the mean GDR was 7.52\u2009mg\/kg\/min (SD 3.67) at baseline versus 8.50\u2009mg\/kg\/min (SD 3.72) at day 28 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.32) and a mean percentage change of \u221213% (0.98). Within Group 2, the mean GDR was 6.54\u2009mg\/kg\/min (SD 1.86) on day 28 versus 5.85\u2009mg\/kg\/min (2.67) on day 72 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.38) mean percentage change \u221211% (\u22120.69). There was no statistically significant change between the groups at baseline (Mean 7.52 [SD 3.67] vs Mean 6.11 [SD 2.94],\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.31), at Day 28 (Mean 8.50 [SD 3.72] vs Mean 6.54 [SD 1.86],\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.27), or at Day 72 (Mean 9.65 [SD 5.07] vs Mean 5.85 [SD 2.67],\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.13). GDR on the final day of administration of bictegravir\/emtricitabine\/tenofovir alafenamide (B\/F\/TAF) was not significantly different (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.104) between Group 1\u2009Day 28 (6.64 [interquartile range (IQR) 5.83, 10.59] mg\/kg\/min) and Group 2\u2009day 72 (0.28 [IQR 3.99, 8.79] mg\/kg\/min).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment with Biktarvy for 28\u2009days was not associated with a statistically significant impact on total body insulin sensitivity as measured using a hyper\u2010insulinaemic\u2010euglycaemic clamp method. However, long\u2010term data on the metabolic effects of Biktarvy are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70208","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:37:17Z","timestamp":1771475837000},"page":"809-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of Biktarvy (B\/F\/\n                    <scp>TAF<\/scp>\n                    ) on whole\u2010body insulin sensitivity, lipid and endocrine profile in healthy volunteers"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4460-8363","authenticated-orcid":false,"given":"Joseph","family":"Heskin","sequence":"first","affiliation":[{"name":"Chelsea and Westminster NHS Foundation Trust  London UK"},{"name":"Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-2481","authenticated-orcid":false,"given":"Roya","family":"Movahedi","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6715-8027","authenticated-orcid":false,"given":"Sujin","family":"Kang","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster NHS Foundation Trust  London UK"},{"name":"Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Byrne","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krestine","family":"Elecito","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster NHS Foundation Trust  London 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UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2213-1103","authenticated-orcid":false,"given":"Marta","family":"Boffito","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster NHS Foundation Trust  London UK"},{"name":"Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000616"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1902824"},{"key":"e_1_2_7_4_1","first-page":"S846","volume-title":"Open Forum Infectious Diseases","author":"Sax 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