{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:03:34Z","timestamp":1784300614133,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In Europe, most people with HIV\u20101(PWH) achieve virologic suppression with effective and well\u2010tolerated antiretroviral therapies (ART). In this context, patient\u2010reported outcomes (PRO) are increasingly important for evaluating ART benefits. This study aimed to describe treatment durability, satisfaction and quality of life (QoL) in virologically suppressed PWH switching to a doravirine\u2010based regimen (PWH\u2010DOR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>DoraVIH was a national, multicentre, real\u2010world cohort study with two phases: cross\u2010sectional and prospective follow\u2010up of PWH\u2010DOR at 3 (M3) and 15\u201318\u2009months (M15\u201318) post\u2010switch. Durability of the doravirine\u2010based regimen was recorded at both follow\u2010up visits, and on\u2010treatment virologic response at M3. QoL was assessed at baseline (D0) and M15\u201318 using the SF\u201036 questionnaire. Pre\u2010switch patient satisfaction with treatment was assessed at D0 using the HIV Treatment Satisfaction Questionnaire (HIVTSQs), and post\u2010switch at M3 and M15\u201318 using the HIVTSQc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 143 PWH\u2010DOR\u00a0included (mean age 51.1\u2009\u00b1\u200910.6\u2009years; 68% men), durability was 94% (131\/140) at M3 and 83% (114\/138) at M15\u201318. All participants receiving doravirine at M3 remained virologically suppressed. SF\u201036 scores showed no significant QoL change between D0 (72.6\u2009\u00b1\u200917.2) and M15\u201318 (73.0\u2009\u00b1\u200919.6). Pre\u2010switch treatment satisfaction averaged 50.2\u2009\u00b1\u20099.6 (HIVTSQs score). Most PWH\u2010DOR reported better satisfaction (HIVTSQc score &gt;0): 90% at M3 (96\/107) and 90% at M15\u201318 (89\/99).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite the absence of a control group and limited sample size, these real\u2010world data support the effectiveness of switching to a doravirine\u2010based regimen, with high durability and improved patient satisfaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70210","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T03:11:08Z","timestamp":1771557068000},"page":"886-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment durability, satisfaction and quality of life in virologically suppressed\n                    <scp>HIV<\/scp>\n                    \u20101 people switching to doravirine: Results from the French study\n                    <scp>DoraVIH<\/scp>"],"prefix":"10.1111","volume":"27","author":[{"given":"Bruno","family":"Spire","sequence":"first","affiliation":[{"name":"Aix Marseille University, Inserm, IRD, SESSTIM Economic &amp; Social Sciences of Health &amp; Medical Information Processing, ISSPAM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Robineau","sequence":"additional","affiliation":[{"name":"CH Tourcoing  Tourcoing France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Pourcher","sequence":"additional","affiliation":[{"name":"AP\u2010HP Piti\u00e9 Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Loubet","sequence":"additional","affiliation":[{"name":"CHU N\u00eemes  N\u00eemes 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