{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T17:54:58Z","timestamp":1794246898419,"version":"4.9.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK125162"],"award-info":[{"award-number":["K23DK125162"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tenofovir disoproxil fumarate, lamivudine and dolutegravir (TLD) have become the first\u2010line antiretroviral regimen in national HIV treatment programs throughout Southern Africa, including in South Africa. This is largely due to the excellent efficacy, tolerability and affordability. However, this transition to TLD has also been associated with excess weight gain and new\u2010onset obesity in both new initiators of antiretroviral therapy (ART) and those who transition to TLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted one\u2010time, in\u2010depth, semi\u2010structured interviews with 26 overweight or obese people living with HIV with a body mass index \u226530\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      in rural KwaZulu\u2010Natal. The Causal Continuum Model for Obesity was used to guide the development of data collection instruments and the analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most participants expressed a wish for a slightly smaller body size as ideal. However, they simultaneously rejected the notion of a desire to appear thin, associating thinness with illness. They also expressed concern about stigma from family and friends if they were to experience rapid or large weight loss. We also found that overweight and obese people living with HIV in this rural community consistently associated large body sizes with an increased risk of high blood pressure, diabetes and other health complications. Lastly, the participants expressed an interest in exercise\u2010based and pharmacologic interventions to prevent weight gain or promote weight loss in particular, but had little interest in diet modification for this purpose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Efforts to develop interventions to address obesity in people living with HIV should consider those that include exercise or pharmacologic anti\u2010obesity therapies in their design and implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70216","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:26:10Z","timestamp":1777425970000},"page":"935-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preventing weight gain for people living with\n                    <scp>HIV<\/scp>\n                    in rural\n                    <scp>KwaZulu<\/scp>\n                    \u2010Natal, South Africa: A qualitative study of perspectives and strategies"],"prefix":"10.1111","volume":"27","author":[{"given":"Thabang","family":"Manyaapelo","sequence":"first","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nondumiso","family":"Mpanza","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thabisile","family":"Mjilo","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samukelisiwe","family":"Nxumalo","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gugulethu","family":"Shazi","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taing Nandi","family":"Aung","sequence":"additional","affiliation":[{"name":"Medical Practice Evaluation Center, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-2523","authenticated-orcid":false,"given":"Alisha","family":"Wade","sequence":"additional","affiliation":[{"name":"School of Public Health, University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0003-0168","authenticated-orcid":false,"given":"Jacques","family":"du Toit","sequence":"additional","affiliation":[{"name":"School of Public Health, University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smart","family":"Mabweazara","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"McCluskey","sequence":"additional","affiliation":[{"name":"Medical Practice Evaluation Center, Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Division of Infectious Diseases Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"College of Health Sciences, University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nomathemba","family":"Chandiwana","sequence":"additional","affiliation":[{"name":"Desmond Tutu HIV Center, University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3506-842X","authenticated-orcid":false,"given":"Mark J.","family":"Siedner","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"},{"name":"Medical Practice Evaluation Center, Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Division of Infectious Diseases Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"College of Health Sciences, University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Seeley","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"},{"name":"London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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Francois","family":"Venter","sequence":"additional","affiliation":[{"name":"Ezintsha, University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9295-0035","authenticated-orcid":false,"given":"Jen","family":"Manne\u2010Goehler","sequence":"additional","affiliation":[{"name":"Medical Practice Evaluation Center, Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Division of Infectious Diseases Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1902824"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30241-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab444"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003888"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz999"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad545"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac291"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.26268"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-023-04152-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(24)00151-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2024.v114i3.1927"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2021.2012556"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980015001688"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0001221"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30104-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25213"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae260"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/heapro\/das038"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3028-7"},{"key":"e_1_2_9_21_1","volume-title":"Qualitative Research Design: an Interactive Approach","author":"Maxwell J","year":"2005"},{"key":"e_1_2_9_22_1","volume-title":"NVIVO 12","author":"Lumivero","year":"2022"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/16070658.2011.11734348"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-023-02186-5"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-7091-8"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:12:36Z","timestamp":1784297556000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/hiv.70216"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70216","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}