{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:03:35Z","timestamp":1784300615148,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Men who have sex with men living with HIV (MSMLWH) are at highest risk for human papillomavirus (HPV)\u2010associated anal cancer, which may originate from the anal canal, verge or perianal skin. Perianal lesions are frequently overlooked during examination, and their (pre)malignant burden in this population remains poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 308 MSMLWH who underwent high\u2010resolution anoscopy (HRA)\u2010guided perianal biopsy between 2018 and 2024 were analysed. Demographics, clinical HIV parameters, smoking history, HPV vaccination status, anal cytology, high\u2010risk HPV test results and histologic diagnoses were collected. Risk factors for perianal (pre)cancer were assessed using chi\u2010square and rank\u2010sum tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age was 52\u2009years (range 27\u201372). Prevalence of abnormal anal cytology (atypical squamous cells of undetermined significance [ASCUS] or worse), high\u2010risk HPV and HPV16 was 85%, 77% and 30%, respectively. Intra\u2010anal high\u2010grade squamous intraepithelial lesion (HSIL) was detected in 48%. Histologic diagnoses of perianal lesions included negative (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912, 4%), low\u2010grade squamous intraepithelial lesions (LSIL) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009236, 77%), HSIL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955, 18%), basal cell carcinoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091, &lt;1%) and superficially invasive squamous cell carcinoma (SISCCA,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094, 1%). Perianal HSIL without intra\u2010anal HSIL occurred in 8% of participants, with 82% of HSILs found in verrucous lesions. Perianal HSIL\/SISCCA was strongly associated with high\u2010risk HPV, HPV16 and intra\u2010anal HSIL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). HPV16 was the strongest predictor (odds ratio [OR] 5.6; 95% CI 2.9\u201310.8).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Perianal lesions in MSMLWH have significant (pre)malignant potential, particularly in the context of HPV16 infection. Thorough examination and low threshold for biopsy are essential for effective cancer prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70218","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:58:55Z","timestamp":1772999935000},"page":"959-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perianal lesions in men who have sex with men living with\n                    <scp>HIV<\/scp>\n                    : Risk of precancer and cancer"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-6305","authenticated-orcid":false,"given":"Shima","family":"Rastegar","sequence":"first","affiliation":[{"name":"Division of Gynecologic Pathology, Department of Pathology Icahn School of Medicine at Mount Sinai  New York New York 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-280X","authenticated-orcid":false,"given":"Grace","family":"Rabinowitz","sequence":"additional","affiliation":[{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Sigel","sequence":"additional","affiliation":[{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Pathology, Department of Pathology Icahn School of Medicine at Mount Sinai  New 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