{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:08Z","timestamp":1787014328544,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize real\u2010world treatment switching in France to bictegravir (BIC or B) or dolutegravir (DTG)\u2010based regimens with a focus on treatment persistence, effectiveness (HIV\u20101 RNA \u226450 copies\/ml) and particular attention to the prevalence and incidence of comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>People living with HIV from the prospective ANRS\u2010CO3\u2010AquiVIH\u2010NA cohort, who switched from effective antiretroviral treatment (ART) to a BIC\u2010 or DTG\u2010based regimen between 2018 and 2021, were eligible for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2275 people living with HIV were included (52% receiving B\/F\/TAF, 8% DTG\/3TC\/ABC, 18% DTG\/RPV, 22% DTG\/3TC) with a median age of 53\u201356\u2009years and a comorbidity prevalence of 71%\u201375% across treatment groups (chronic kidney disease (CKD) 15%\u201325%, diabetes mellitus 15%\u201319%, hypertension 57%\u201364%).<\/jats:p>\n                    <jats:p>Viral suppression rates at month 18 (LOCF, last observation carried forward) using a missing\u2010equals\u2010excluded (M\u2009=\u2009E) approach were 97% on B\/F\/TAF, 95% on DTG\/3TC\/ABC, 97% on DTG\/RPV and 96% on DTG\/3TC. Discontinuation rates were 16.5% for B\/F\/TAF, 37.5% for DTG\/3TC\/ABC, 16.7% for DTG\/RPV and 17.3% for DTG\/3TC, driven by adverse events in 5.6%, 12.5%, 5.6% and 6.1%, respectively.<\/jats:p>\n                    <jats:p>Comorbidity incidence rates\/1000 person years in those free of the respective disease were 39 for hypertension, 22 for diabetes mellitus, 13 for cardiovascular events and 5 for CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real\u2010world cohort, treatment persistence 18\u2009months after therapy switch was similar for B\/F\/TAF, DTG\/RPV and DTG\/3TC, but significantly lower for DTG\/3TC\/ABC. All regimens maintained high levels of viral suppression. Furthermore, the cohort illustrates the disease burden experienced by middle\u2010aged and elderly people living with HIV and highlights the importance of adapting ART to the specific needs of this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70220","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:06:44Z","timestamp":1773029204000},"page":"965-978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010world use of second\u2010generation integrase strand transfer inhibitors (\n                    <scp>INSTI<\/scp>\n                    ) as switch therapy in the prospective\n                    <scp>ANRS<\/scp>\n                    \u2010\n                    <scp>CO3<\/scp>\n                    \u2010\n                    <scp>AquiVIH<\/scp>\n                    \u2010\n                    <scp>NA<\/scp>\n                    cohort"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-0608","authenticated-orcid":false,"given":"O.","family":"Leleux","sequence":"first","affiliation":[{"name":"Bordeaux Population Health Research Center, INSERM U1219, CIC\u2010EC 1401, Univ. 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