{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:04:07Z","timestamp":1784300647131,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceutica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore missed opportunities for PrEP use among people with recently acquired HIV in the United Kingdom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were derived from CASCADE, an international, longitudinal, mixed\u2010methods study of adults (\u226516\u2009years) with recently acquired HIV (\u226412\u2009months). Individuals were recruited from nine UK clinics (08\/2022\u201309\/2024) to self\u2010complete a questionnaire; a subset participated in semi\u2010structured interviews (SSIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>46 questionnaires were completed (39 cisgender men and 7 women, including 2 transgender women) and 11 SSIs (1 cisgender woman). Among men, 22 perceived HIV risk before diagnosis; 21 had \u22655 sexual partners and 17 reported group sex in the 3\u2009months before diagnosis. Thirty (29 men and 1 woman) reported sexualized drug use. Twenty men had ever used PrEP; seven of them had not used it in the 6 months prior to diagnosis. No women had ever used PrEP. Most gay, bisexual and other men who have sex with men (GBMSM) were aware of PrEP; however, risk perception, social meanings of PrEP and concerns about side effects hindered utilization. Among five men using event\u2010based dosing (EBD), three described difficulty predicting sexual activity that led to missed or mistimed pre\u2212\/post\u2010sex doses \u2013 while others were reluctant to take daily PrEP. For women, the biggest barrier was lack of awareness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PrEP barriers vary by population. For GBMSM, addressing barriers to uptake\/adherence (e.g., EBD challenges) are key, highlighting the potential benefit of long\u2010acting injectables. However, awareness of PrEP remains a key challenge for women to achieve equity in prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70222","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:14:53Z","timestamp":1773962093000},"page":"979-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Missed opportunities to prevent\n                    <scp>HIV<\/scp>\n                    acquisition with pre\u2010exposure prophylaxis: A mixed methods study of people with recently acquired\n                    <scp>HIV<\/scp>\n                    in the\n                    <scp>United Kingdom<\/scp>"],"prefix":"10.1111","volume":"27","author":[{"given":"Argyro","family":"Karakosta","sequence":"first","affiliation":[{"name":"Medical School of Athens National and Kapodistrian University of Athens  Athens Greece"},{"name":"Department of Social Work University of West Attica  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2061-8361","authenticated-orcid":false,"given":"Emily Jay","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Institute for Global Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2666-0125","authenticated-orcid":false,"given":"Flavien","family":"Coukan","sequence":"additional","affiliation":[{"name":"Institute for Global Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diarmuid","family":"Nugent","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Reeves","sequence":"additional","affiliation":[{"name":"Homerton Healthcare NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1379-1775","authenticated-orcid":false,"given":"Laura","family":"Waters","sequence":"additional","affiliation":[{"name":"Institute for Global Health University College London  London UK"},{"name":"Central &amp; North West London NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1676-7583","authenticated-orcid":false,"given":"Sarah","family":"Fidler","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Imperial College London, Imperial College NIHR BRC  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0529-0372","authenticated-orcid":false,"given":"Elisa Ruiz","family":"Burga","sequence":"additional","affiliation":[{"name":"Institute of Health Informatics University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Fox","sequence":"additional","affiliation":[{"name":"Guys and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Uriel","sequence":"additional","affiliation":[{"name":"Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Mackintosh","sequence":"additional","affiliation":[{"name":"Clinical Infection Research Group NHS Lothian  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-7727","authenticated-orcid":false,"given":"Shema","family":"Tariq","sequence":"additional","affiliation":[{"name":"Institute for Global Health University College London  London UK"},{"name":"Central &amp; 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