{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:19:25Z","timestamp":1783448365217,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Aging people with HIV are increasingly affected by multimorbidity and polypharmacy, which heighten the risk of drug\u2013drug interactions (DDIs) and potentially inappropriate medications (PIMs). This study evaluated a multidisciplinary, AI\u2010supported quality improvement intervention designed to optimize polypharmacy management in older people with HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>People with HIV aged \u226550\u2009years attending the Modena HIV Metabolic Clinic (MHMC) were invited to submit photos of their medications via WhatsApp. Images were processed by AI for optical character recognition and automatically reconciled with the electronic patient chart (EPC). AI recognition accuracy was 94% when validated against manual review. Pharmacists reviewed AI\u2010generated reports from the NavFarma\u00ae decision support system, generated alerts for PIM, defined according to Beers and the STOPP\/START criteria, DDIs, anticholinergic burden (ACB), and risks of QTc prolongation and nephrotoxicity. Primary outcome was agreement between patient\u2010reported and EPC\u2010recorded medications. Secondary outcomes included pill burden, total prescribed drugs and actionable alerts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 181 participants (median age 63\u2009years; 72% male), 111 (61.3%) showed complete agreement between EPC and patient lists, while 70 (38.7%) had discrepancies. Pharmacist evaluation identified major DDIs in 70.4% of cases, ACB in 26.5%, QTc\u2010prolonging drugs in 81.6% and nephrotoxic agents in 95.9%. Participants with \u226510 total prescribed drugs had higher frailty, pill burden and PIM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AI\u2010assisted medication reconciliation combined with pharmacist review improved the identification of PIM and medication\u2010related risks, supporting safer prescribing in people with HIV. This model aligns with international calls to improve prescribing safety and offers a scalable framework for integrating digital tools into multidisciplinary HIV care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70234","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:45:31Z","timestamp":1775893531000},"page":"1109-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A multidisciplinary,\n                    <scp>AI<\/scp>\n                    \u2010supported quality improvement intervention to manage polypharmacy in aging people with\n                    <scp>HIV<\/scp>"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9806-8470","authenticated-orcid":false,"given":"Jovana","family":"Milic","sequence":"first","affiliation":[{"name":"Department of Surgical, Medical, Dental and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Distribuzione Diretta AUSL Modena, Dipartimento Farmaceutico Interaziendale  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Belli","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Dental and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luca","family":"Lonardi","sequence":"additional","affiliation":[{"name":"Engineering Informatics  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Ruffilli","sequence":"additional","affiliation":[{"name":"School of Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Albano","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic Azienda Ospedaliero\u2010Universitaria, Policlinico of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Visicaro","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic Azienda Ospedaliero\u2010Universitaria, Policlinico of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Ricciardetto","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic Azienda Ospedaliero\u2010Universitaria, Policlinico of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi De","family":"Cosmo","sequence":"additional","affiliation":[{"name":"Infologic Srl  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Mussi","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences and Center for Gerontological Evaluation and Research University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gandolfi","sequence":"additional","affiliation":[{"name":"Distribuzione Diretta AUSL Modena, Dipartimento Farmaceutico Interaziendale  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mussini","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Dental and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Engineering Informatics  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Grana","sequence":"additional","affiliation":[{"name":"Enzo Ferrari Department of Engineering University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-3914","authenticated-orcid":false,"given":"Giovanni","family":"Guaraldi","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Dental and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Engineering Informatics  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002349"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-018-0789-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7954"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir627"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa918"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18372"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.70129"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.70002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1097238"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-023-01064-y"},{"issue":"71","key":"e_1_2_10_12_1","first-page":"2052","article-title":"Updated AGS beers criteria\u00ae for potentially inappropriate medication use in older adults","volume":"2023","author":"American Geriatrics Society","year":"2023","journal-title":"J Am Geriatr Soc"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.7.722"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000753"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13542"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2217\/1745509X.4.3.311"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-03021-3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad292"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-023-01037-1"},{"key":"e_1_2_10_20_1","unstructured":"WHO Medication Without Harm.2024.https:\/\/www.who.int\/initiatives\/medication-without-harm"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(25)00047-5"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304146"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18132"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocy115"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2013-001995"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz811"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkae190"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.1047"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxac224"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007107"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3335"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad348"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa329"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-019-02785-z"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70234","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:08:57Z","timestamp":1783447737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,11]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/hiv.70234"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70234","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,11]]},"assertion":[{"value":"2026-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}