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Unfortunately, many of these conditions remain undiagnosed, and systematic screening in clinical practice remains limited. Therefore, we aimed to assess the burden of unrecognized age\u2010related comorbidities in a clinical outpatient setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional cohort study was conducted from November 2023 to March 2025 at the HIV outpatient clinic, Copenhagen University Hospital, Rigshospitalet. A structured screening procedure was implemented to assess unrecognized comorbidities among PWH aged \u226560\u2009years. The screening comprised multiple guideline\u2010recommended risk evaluations, including 10\u2010year cardiovascular risk score (SCORE2), 10\u2010year fracture risk assessment (FRAX), assessment of chronic lung disease and frailty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 387\/532 (72.7%) eligible patients participated. Of patients without a history of cardiovascular disease, 203\/300 (67.6%) were categorized as high risk and 57\/300 (19%) as very\u2010high risk by SCORE2. Primary preventive lipid\u2010lowering therapy was prescribed in 75\/203 (36.9%) and 18\/57 (31.6%) in the high\u2010risk and very\u2010high risk groups, respectively. Of participants without prior chronic lung disease, 29\/324 (9%) reported symptoms, and 20\/260 (7.7%) with available spirometry had airflow limitation. Among PWH without a history of osteoporosis, 127\/335 (37.9%) were categorized as high risk of major fracture and\/or hip fracture. Pre\u2010frailty or frailty was identified in 88\/387 (22.7%) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The considerable burden of unrecognized age\u2010related comorbidities in PWH \u226560\u2009years of age highlights the need for a systematic approach to early detection and preventative management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70238","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T13:34:46Z","timestamp":1776605686000},"page":"1144-1155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systematic screening for age\u2010related comorbidities: Health care optimization among persons with\n                    <scp>HIV<\/scp>\n                    in an outpatient setting"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0715-4403","authenticated-orcid":false,"given":"Anna Katrine Haslund","family":"Roed","sequence":"first","affiliation":[{"name":"Viro\u2010Immunology Research Unit, Department of Infectious Diseases Copenhagen University Hospital  Rigshospitalet Denmark"},{"name":"Department of Infectious Diseases Copenhagen University Hospital  Rigshospitalet Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-3289","authenticated-orcid":false,"given":"Anne\u2010Mette","family":"Lebech","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital  Rigshospitalet Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  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