{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:19:17Z","timestamp":1783448357351,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The COVID\u201019 pandemic caused substantial disruption in healthcare, particularly in the monitoring and diagnosis of chronic diseases such as HIV infection. The reduction in diagnoses during the pandemic raised doubts about whether there was a true decrease in incidence or a higher rate of occult infection. Given guidelines' recommendations on using indicator conditions (ICs) for requesting HIV serology tests, it was proposed to study whether there was a change in missed diagnostic opportunities (MDOs). The main aim was to analyze the frequency of MDO in people living with HIV (PLWHIV) diagnosed in the pre\u2010pandemic, pandemic and post\u2010pandemic periods. Secondary aims included the frequency of late diagnosis (LD) and its relationship with clinical and sociodemographic characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is an observational, retrospective, single\u2010center study that included PLWHIV diagnosed between 2018 and 2023. The 5\u2009years prior to diagnosis were reviewed to identify MDO, segmented by level of care. Clinical, immunovirological and follow\u2010up variables were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 198 PLWHIV, 32.8% had at least one MDO. No differences were observed between periods, although there was a non\u2010significant downward trend in the post\u2010pandemic period. A total of 49.5% had an LD, which was associated with higher mortality (9.3% vs. 0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). MDOs were more frequent in primary care and among heterosexuals. LD was more common in non\u2010Spanish born.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MDOs did not increase during the pandemic. High rates of LD and MDOs persist, especially for certain patient profiles. These findings reinforce the need to implement systematic screening strategies based on indicator conditions to improve early diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70243","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:46:52Z","timestamp":1776224812000},"page":"1177-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of the\n                    <scp>COVID<\/scp>\n                    \u201019 pandemic on missed opportunities for diagnosis of\n                    <scp>HIV<\/scp>\n                    infection:\n                    <scp>HUCS<\/scp>\n                    \u2010\n                    <scp>ODIPER<\/scp>\n                    (missed diagnostic opportunities) study"],"prefix":"10.1111","volume":"27","author":[{"given":"Ibon","family":"Henales Iruzubieta","sequence":"first","affiliation":[{"name":"Internal Medicine Department Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Romero Mar\u00edn","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Patr\u00f3n Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"P\u00e9rez Stachowski","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"del Arco Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Prada Pardal","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Olalla Sierra","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Fern\u00e1ndez S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Microbiology Department San Cecilio University Hospital  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Soler M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Epidemiology Department Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Rivas Ru\u00edz","sequence":"additional","affiliation":[{"name":"Research and Innovation Unit Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"de la Torre Lima","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Jim\u00e9nez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Vigilancia Epidemiol\u00f3gica del VIH y sida en Espa\u00f1a 2023: Sistema de Informaci\u00f3n sobre Nuevos Diagn\u00f3sticos de VIH y Registro Nacional de Casos de Sida [HIV, STI and Hepatitis Surveillance Unit. HIV and AIDS Epidemiological Surveillance in Spain 2023: Information System on New HIV Diagnoses and National AIDS Case Registry]","author":"Unidad de vigilancia de VIH, ITS y hepatitis","year":"2024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimce.2022.12.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2024.05.006"},{"key":"e_1_2_11_5_1","volume-title":"Ministry of Health","author":"HIV service tracking in 2020 in Spain; impact of COVID\u201019","year":"2020"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20116051"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-022-03771-w"},{"key":"e_1_2_11_8_1","volume-title":"Temporal Trends and Impact of COVID\u201019 on the HIV Cascade of Care across Europe between 2016\u20132021","author":"Fursa O","year":"2023"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12123882"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003164"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-022-00496-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-10296-9"},{"key":"e_1_2_11_13_1","unstructured":"Evaluaci\u00f3n del impacto de la COVID\u201019 en los centros de atenci\u00f3n a ITS\/VIH (redes EPI\u2010ITS y EPI\u2010VIH) en Espa\u00f1a [Evaluation of the impact of COVID\u201019 on STI\/HIV care centers (EPI\u2010ITS and EPI\u2010HIV networks) in Spain] Reguero Rodr\u00edguez de Li\u00e9banaL Hernando Sebasti\u00e1nV et al.Poster presented at the virtual meeting of Seisida.Separados por la covid\u201019 pero m\u00e1s juntos que nunca c held on October 5\u20136.2021."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckad010"},{"key":"e_1_2_11_15_1","article-title":"Impacto de la pandemia de la COVID\u201019 en los sistemas de vigilancia epidemiologica de la infecci\u00f3n por VIH en Espa\u00f1a [impact of the covid\u201019 pandemic on the epidemiological surveillance systems of hiv infection in Spain]","volume":"97","author":"Hernando Sebasti\u00e1n V","year":"2023","journal-title":"Rev Esp Salud Publica"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2010.00857.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016209787581535"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.01.017"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249864"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32801138f7"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052845"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220108"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimce.2021.12.010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4321\/S1137-66272014000300003"},{"key":"e_1_2_11_25_1","unstructured":"Ministerio de Sanidad SS e IPN sobre S.Gu\u00eda de recomendaciones para el diagn\u00f3stico precoz del VIH en el \u00e1mbito sanitario [Guidelines for early HIV diagnosis in healthcare settings]. Direcci\u00f3n General de Salud P\u00fablica.2014."},{"key":"e_1_2_11_26_1","first-page":"416","article-title":"Recomendaciones dirigidas a los servicios de urgencias para el diagn\u00f3stico precoz de pacientes con sospecha de infecci\u00f3n por VIH y su derivaci\u00f3n para estudio y seguimiento. [Recommendations for Emergency Departments on the early diagnosis of patients with suspected HIV infection and their referral for evaluation and follow\u2010up]","volume":"32","author":"Gonz\u00e1lez Del Castillo J","year":"2020","journal-title":"Emergencias"},{"key":"e_1_2_11_27_1","volume-title":"Copenhagen","author":"HIV Indicator Conditions: Guidance for Implementing HIV Testing in Adults in Health Care Settings","year":"2012"},{"key":"e_1_2_11_28_1","unstructured":"HIV indicator conditions: guidance for implementing HIV testing in adults in health care settings.eurotest.org"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2018.03.007"},{"issue":"3","key":"e_1_2_11_30_1","first-page":"138","article-title":"Targeting fast\u2010track goals: missed opportunities for HIV testing in the Community of Madrid","volume":"40","author":"Gallego\u2010M\u00e1rquez N","year":"2022","journal-title":"Enferm Infecc Microbiol Clin (Engl Ed)"},{"issue":"11","key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.medcli.2018.05.031","article-title":"Diagn\u00f3stico tard\u00edo de la infecci\u00f3n por VIH: oportunidades perdidas [Late diagnosis of HIV infection: missed opportunities]","volume":"152","author":"Mart\u00ednez\u2010Sanz J","year":"2019","journal-title":"Med Clin (Barc)"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare12030361"},{"key":"e_1_2_11_33_1","volume-title":"HIV\/AIDS surveillance in Europe 2024","author":"European Centre for Disease Prevention and Control\/WHO Regional Office for Europe","year":"2024"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2016.1178700"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100877"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0036933013496965"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13080683"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2019.09.006"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2024.29.48.2400138"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2020-054697"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2017.07.010"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462419868637"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-72"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2015-052328"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002735"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:08:34Z","timestamp":1783447714000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/hiv.70243"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70243","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]},"assertion":[{"value":"2025-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}