{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:38:03Z","timestamp":1792618683626,"version":"4.5.0"},"reference-count":5,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>HIV\u2010tuberculosis coinfection remains a major global health challenge and the concomitant use of antiretroviral therapy with rifampicin\u2010based tuberculosis treatment is frequently complicated by clinically relevant drug\u2010drug interactions. Rifampicin strongly induces CYP3A4 and UGT1A1 enzymes, leading to significant reductions in plasma concentrations of several integrase strand transfer inhibitors, including bictegravir. As a result, recommended strategies usually involve modifying antiretroviral therapy to rifampicin\u2010compatible regimens such as dolutegravir administered twice daily or using rifabutin\u2010based tuberculosis therapy. However, these alternatives may not always be feasible or well tolerated in routine clinical practice. Increasing pharmacokinetic understanding of bictegravir and emerging clinical data suggest that dose intensification may partially overcome rifampicin\u2010induced reductions in drug exposure. In this letter, we explore the potential role of bictegravir\/emtricitabine\/tenofovir alafenamide administered twice daily during rifampicin\u2010based tuberculosis treatment as a pragmatic option in selected patients when standard therapeutic approaches cannot be used.<\/jats:p>","DOI":"10.1111\/hiv.70245","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T14:45:06Z","timestamp":1776696306000},"page":"1376-1377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Twice\u2010daily bictegravir during rifampicin\u2010based tuberculosis therapy: A pragmatic alternative"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0539-3301","authenticated-orcid":false,"given":"Juan Gabriel","family":"S\u00e1nchez\u2010Cano","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Madrid Spain"},{"name":"Internal Medicine Unit Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mu\u00f1oz\u2010Echeverr\u00eda","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Casco\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Moreno\u2010N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_1_5_2_1","unstructured":"CustodioJM WestS YuA et al.Pharmacokinetics of bictegravir coadministered with rifampin in healthy volunteers. Presented at: Conference on Retroviruses and Opportunistic Infections (CROI).2018."},{"issue":"8","key":"e_1_2_1_5_3_1","first-page":"1026","article-title":"Once\u2010weekly rifapentine and isoniazid for tuberculosis prevention in patients with HIV receiving dolutegravir\u2010based antiretroviral therapy","volume":"62","author":"Dooley KE","year":"2016","journal-title":"Clin Infect Dis"},{"key":"e_1_2_1_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz256"},{"key":"e_1_2_1_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02406-20"},{"key":"e_1_2_1_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(25)00200-0"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70245","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:41:17Z","timestamp":1792615277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":5,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/hiv.70245"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70245","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}