{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:37:53Z","timestamp":1792618673951,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Two\u2010drug regimens (2DRs) may reduce long\u2010term drug toxicities and drug\u2010drug interactions for people with HIV (PWH) on antiretroviral therapy (ART). This study evaluated clinical and laboratory outcomes in PWH who switched from standard ART to dolutegravir and lamivudine (DTG\u2009+\u20093TC) in real\u2010world settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively identified virally suppressed PWH who switched from standard ART to DTG\u2009+\u20093TC at Queen Elizabeth Hospital, Hong Kong, China. They were grouped by age (PWH &lt;50\u2009years: PWH\u2009&lt;\u200950; PWH\u2009&gt; =50\u2009years: PWH\u2009&gt;\u2009=50). Their demographics, clinical and laboratory data before and 48\u2009weeks after switch were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Subjects included 352 PWH (84.7% male, 48.7% PWH\u2009&gt;\u2009=50, median ART duration 8.3\u2009years). At 48\u2009weeks post\u2010switch, 96.0% maintained DTG\u2009+\u20093TC with two (1.1%) in the PWH\u2009&lt;\u200950 and three (1.7%) in the PWH\u2009&gt;\u2009=50 experienced virological failure. There was no significant difference in virological failure (hazard ratio (HR) 0.63, 95% confidence interval (CI) 0.11, 3.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.613) or 2DR discontinuation (HR 0.95, 95% CI 0.33, 2.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.926; restricted mean survival time (RMST) difference 0.23\u2009weeks, 95% CI \u22120.64, 1.10,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.600) between the groups. PWH\u2009&gt;\u2009=50 exhibited a greater total cholesterol reduction than PWH\u2009&lt;\u200950 post\u2010switch (median change \u22124.8% (IQR \u221217.5%, 5.9%) versus 0.4% (IQR \u22128.1%, 8.2%),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). Two sensitivity analyses excluding lipid\u2010lowering drug users and restricting to INSTI\u2010based ART users before switch yielded negative results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this Chinese\u2010majority cohort, switching from standard ART to DTG\u2009+\u20093TC was well tolerated at 48\u2009weeks by both younger and older PWH. Despite more comorbidities in PWH\u2009&gt;\u2009=50, their changes in laboratory outcomes post\u2010switch were comparable to PWH\u2009&lt;\u200950.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70247","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:26:51Z","timestamp":1777944411000},"page":"1241-1252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010world clinical and laboratory changes after switching to two\u2010drug regimen in\n                    <scp>HIV<\/scp>\n                    \u2010suppressed individuals: 48\u2009weeks and beyond"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6476-4697","authenticated-orcid":false,"given":"Tommy Hing\u2010cheung","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-0449","authenticated-orcid":false,"given":"Ruby Tsz\u2010shan","family":"Kwong","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-4409","authenticated-orcid":false,"given":"Phillip","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Yale Center for Brain and Mind Health, Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok\u2010wai","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Shuk\u2010ying","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5957-6838","authenticated-orcid":false,"given":"Man\u2010yee","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak\u2010chiu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8377-085X","authenticated-orcid":false,"given":"Wai\u2010shing","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics Kwong Wah Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai\u2010kwong","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010man","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel Kai\u2010tung","family":"Choy","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe Lok\u2010fung","family":"Tung","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason Ka\u2010wah","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics Kwong Wah Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Kai\u2010yeung","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man\u2010po","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)33095\u20107"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa356"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002449"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1243"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac036"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac130"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32462\u20100"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.22246"},{"key":"e_1_2_12_10_1","unstructured":"The U.S. Food and Drug Administration.Human Immunodeficiency Virus\u20101 Infection: Developing Antiretroviral Drugs for Treatment Guidance for Industry.2015."},{"key":"e_1_2_12_11_1","unstructured":"European AIDS Clinical Society.EACS Guidelines version 12.0 October 2023 [Internet].2023Available from:https:\/\/www.eacsociety.org\/media\/guidelines-12.0.pdf"},{"key":"e_1_2_12_12_1","unstructured":"British HIV Association.BHIVA guidelines on antiretroviral treatment for adults living with HIV\u20101 2022 (2025 interim update) [Internet].2025Available from:https:\/\/bhiva.org\/wp\u2010content\/uploads\/2025\/10\/BHIVA\u2010guidelines\u2010on\u2010antiretroviral\u2010treatment\u2010for\u2010adults\u2010living\u2010with\u2010HIV\u20101\u20102025\u2010interim\u2010update.pdf"},{"key":"e_1_2_12_13_1","unstructured":"United States Department of Health and Human Services.Laboratory Testing for Initial Assessment and Monitoring of People With HIV Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV [Internet].2025Available from:https:\/\/clinicalinfo.hiv.gov\/en\/guidelines\/hiv\u2010clinical\u2010guidelines\u2010adult\u2010and\u2010adolescent\u2010arv\/tests\u2010initial\u2010assessment\u2010follow\u2010up"},{"issue":"2","key":"e_1_2_12_14_1","first-page":"1183","article-title":"The Hong Kong Hospital Authority's information architecture","volume":"107","author":"Cheung NT","year":"2004","journal-title":"Stud Health Technol Inform"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999\u2010018\u20100148\u2010x"},{"key":"e_1_2_12_16_1","unstructured":"United States Department of Health and Human Services.HIV and the Older Person Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV [Internet].2024Available from:https:\/\/clinicalinfo.hiv.gov\/en\/guidelines\/hiv\u2010clinical\u2010guidelines\u2010adult\u2010and\u2010adolescent\u2010arv\/special\u2010populations\u2010hiv\u2010and\u2010older\u2010person"},{"key":"e_1_2_12_17_1","unstructured":"European Centre for Disease Prevention and Control.European standards of HIV prevention and care: module on HIV and co\u2010morbidities [Internet]. Publications Office.2025."},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)32064\u20105"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010150\u20109\u2010200905050\u201000006"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000624"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030\u2010199807000\u201000003"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.13.2050"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1310\/f2v7\u20103r46\u2010vx6j\u2010241r"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0010019"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121\u2010021\u201000522\u20107"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016813"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103018(22)00249\u20101"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13050"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121\u2010024\u201001103\u20100"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/HIV.S452130"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.14.80"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S68396"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000197465.14340.d4"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.09.009"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)61853\u20104"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002011"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20\u20104853"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201078656\u20100"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105893"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13432"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12468"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000445"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:41:30Z","timestamp":1792615290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/hiv.70247"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70247","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]},"assertion":[{"value":"2025-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}