{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:53:48Z","timestamp":1790952828082,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["TMA2017GSF\u20101962"],"award-info":[{"award-number":["TMA2017GSF\u20101962"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The burden of cardiometabolic diseases (CMDs) is rising in people with HIV (PWH). While extensive data exist on CMD prevalence in PWH receiving antiretroviral therapy (ART), comprehensive data on ART\u2010na\u00efve PWH are scarce. We aimed to estimate the global prevalence of hypertension, diabetes, obesity and dyslipidaemia among ART\u2010na\u00efve PWH and compare estimates with those on ART and HIV\u2010negative populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis included a search of PubMed\u2010MEDLINE, CINAHL, SCOPUS, Academic Search Premier, Africa\u2010Wide Information and Africa\u2010Journals Online for original articles published up to June 2024. Cross\u2010sectional, cohort and case\u2010control studies providing baseline data on CMD prevalence were included. Studies had to include ART\u2010na\u00efve PWH aged \u226515\u2009years. Two independent reviewers conducted studies screening, data extraction and methodological quality assessment. A random\u2010effects meta\u2010analysis with double arc\u2010sine transformation was used for prevalence estimates. The study was registered with PROSPERO (CRD42021226001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 184 studies published between 2000 and 2024, involving a total of 424\u2009629 participants. The global pooled prevalence among ART\u2010na\u00efve PWH was 14.2% (95% CI: 12.4\u201316.1) for hypertension, 3.6% (2.9\u20134.3) for diabetes, 11.5% (10.3\u201312.9) for body mass index\u2010based obesity, 18.3% (12.7\u201324.6) for waist circumference\u2010based obesity, 14.8% (12.1\u201317.8) for elevated total cholesterol, 17.6% (11.3\u201324.8) for elevated low\u2010density lipoprotein cholesterol, 22.9% (19.3\u201326.7) for elevated triglycerides and 54.6% (48.2\u201361.0) for low high\u2010density lipoprotein cholesterol, all with high heterogeneity. Significant regional variations in the prevalence of diabetes, obesity and dyslipidaemia were observed according to UNAIDS regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We found a notable prevalence of CMDs in ART\u2010na\u00efve PWH, with significant regional variations in the prevalence of diabetes, obesity and dyslipidaemia. This highlights the need for targeted interventions and early screening to address the growing CMD burden among PWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ART\u2010na\u00efve PWH face a considerable CMD burden, emphasizing the importance of early detection and management. Regional differences in CMD prevalence call for tailored public health strategies and integration of CMD prevention into HIV care protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70254","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T01:16:41Z","timestamp":1778116601000},"page":"1382-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of cardiometabolic diseases among\n                    <scp>ART<\/scp>\n                    \u2010na\u00efve people with\n                    <scp>HIV<\/scp>\n                    : A global systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-5363","authenticated-orcid":false,"given":"Peter Vanes","family":"Ebasone","sequence":"first","affiliation":[{"name":"Department of Medicine University of Cape Town  Cape Town South Africa"},{"name":"Clinical Research Education Networking and Consultancy (CRENC)  Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastase","family":"Dzudie","sequence":"additional","affiliation":[{"name":"Clinical Research Education Networking and Consultancy (CRENC)  Yaounde Cameroon"},{"name":"Faculty of Medicine and Biomedical Sciences University of Yaounde I  Yaounde Cameroon"},{"name":"Lown Scholars Program, Harvard T. 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