{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:38:06Z","timestamp":1792618686810,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012095","name":"Scottish Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the population\u2010level impact of seven years of Scotland's HIV pre\u2010exposure prophylaxis (PrEP) programme among gay, bisexual and other men who have sex with men (GBMSM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>National administrative data were used to estimate PrEP coverage and HIV incidence among 35\u2009342 GBMSM attending specialist sexual health services between July 2015 and March 2024. Poisson regression was used to investigate the risk of HIV acquisition and its association with the extent of PrEP prescribing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PrEP coverage increased from 21% in the initial PrEP period (July 2017 to March 2020) to 45% in the latter period (April 2022 to March 2024). HIV incidence reduced from 4.46 per 1000 person\u2010years in the pre\u2010PrEP period (July 2015 to June 2017) to 1.66 in the initial PrEP period (aIRR 0.37, 95% CI 0.25\u20130.54) and remained stable thereafter. During the entire PrEP period, the risk of HIV acquisition was reduced among those \u2018currently prescribed\u2019 (involving 4 HIV acquisitions among 11\u2009720 person\u2010years) compared to those never prescribed (60 HIV acquisitions among 34\u2009328 person\u2010years) (aIRR 0.19, 95% CI 0.07\u20130.51). Compared to those currently prescribed PrEP, risk was greatest in those prescribed 12+ months ago (11 HIV acquisitions among 3824 person\u2010years) (aIRR 8.13, 95% CI 2.58\u201325.64).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HIV incidence was sustained at a low level as PrEP coverage broadened among GBMSM, but did not reduce further. Efforts to support persistence and re\u2010engagement with PrEP are warranted in those at ongoing risk of HIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70255","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:25:59Z","timestamp":1778243159000},"page":"1298-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sustained effect of\n                    <scp>Scotland's HIV<\/scp>\n                    pre\u2010exposure prophylaxis programme on transmission among gay and bisexual men who have sex with men: Population\u2010based retrospective cohort study"],"prefix":"10.1111","volume":"27","author":[{"given":"Alan","family":"Yeung","sequence":"first","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"},{"name":"Public Health Scotland  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Estcourt","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"},{"name":"NHS Greater Glasgow and Clyde  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Cullen","sequence":"additional","affiliation":[{"name":"Public Health Scotland  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"},{"name":"NHS Greater Glasgow and Clyde  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-4651","authenticated-orcid":false,"given":"Alison","family":"Rodger","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"},{"name":"Institute for Global Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Clutterbuck","sequence":"additional","affiliation":[{"name":"NHS Lothian  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Steedman","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"},{"name":"Scottish Government  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rak","family":"Nandwani","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"},{"name":"Public Health Scotland  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"McCormick","sequence":"additional","affiliation":[{"name":"Public Health Scotland  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6891-6758","authenticated-orcid":false,"given":"Sharon","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"},{"name":"Public Health Scotland  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization.Guidance on oral pre\u2010exposure prophylaxis (PrEP) for serodiscordant couples men and transgender women who have sex with men at high risk of HIV [Internet].2012[cited 2025 May 14].https:\/\/www.who.int\/publications\/i\/item\/9789241503884"},{"key":"e_1_2_11_3_1","unstructured":"European Centre for Disease Prevention and Control.HIV pre\u2010exposure prophylaxis in the EU\/EEA and the UK: implementation standards and monitoring. 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