{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T03:08:26Z","timestamp":1788750506239,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Bone health is negatively affected in people with HIV, and the risks of osteoporosis and fragility fractures are increased. The objective of this study was to describe the characteristics of those accessing bone health screening and identify factors associated with osteoporosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective data were collected from people accessing a large HIV outpatient service between September 2003 and December 2024. Inclusion criteria were age\u2009\u2265\u200960\u2009years. Data were obtained from medical records, including patient demographics and clinical variables. The three most recent Dual Energy X\u2010ray Absorptiometry (DEXA) scans were analysed. Descriptive statistics were used to summarise patient characteristics, and logistic regression was used to identify factors associated with the development of osteoporosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five hundred eighty\u2010eight people (90.1% male, 91% white, 81% Men who have sex with Men, median age 67\u2009years) were analysed. Of these, 79.6% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009468) had at least one DEXA scan. The prevalence of osteopenia and osteoporosis was 52% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009306) and 18% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009106), respectively. Of those with osteopenia at baseline who had DEXA data available, 11.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934) progressed to osteoporosis. Only 29% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931) of individuals with osteoporosis were receiving bisphosphonate therapy. Prolonged duration on anti\u2010retroviral therapy, fractures and low lumbar spine T\u2010scores were risk factors for developing osteoporosis during follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bone health screening uptake was high in this cohort of older people with HIV, but management of established osteoporosis remained suboptimal. Previous fractures and low lumbar spine T\u2010scores identified those at greater risk of progression to osteoporosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70264","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:54:31Z","timestamp":1780458871000},"page":"1460-1467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Screening for bone health in older people with\n                    <scp>HIV<\/scp>\n                    : Uptake and outcomes from a large\n                    <scp>UK<\/scp>\n                    outpatient\n                    <scp>HIV<\/scp>\n                    service"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3133-3486","authenticated-orcid":false,"given":"Rhys","family":"Nicholas","sequence":"first","affiliation":[{"name":"Department of Global Health and Infection Brighton &amp; Sussex Medical School, University of Sussex  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-5644","authenticated-orcid":false,"given":"Kate","family":"Alford","sequence":"additional","affiliation":[{"name":"Department of Global Health and Infection Brighton &amp; Sussex Medical School, University of Sussex  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"The Lawson Unit, Royal Sussex County Hospital, University Hospitals Sussex NHS Foundation Trust  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Vera","sequence":"additional","affiliation":[{"name":"Department of Global Health and Infection Brighton &amp; Sussex Medical School, University of Sussex  Brighton UK"},{"name":"The Lawson Unit, Royal Sussex County Hospital, University Hospitals Sussex NHS Foundation Trust  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-021-00903-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32801022eb"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000353"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2013.0252"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046031"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-018-0665-z"},{"issue":"60","key":"e_1_2_8_8_1","first-page":"385","article-title":"HIV and bone metabolism","volume":"11","author":"Ofotokun I","year":"2011","journal-title":"Discov Med"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2008.05.608"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031506"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000320"},{"key":"e_1_2_8_12_1","unstructured":"AngusB BrookG BoffitoM et al.BHIVA guidelines on the routine investigation and monitoring of HIV\u20101 positive adults 1 BHIVA guidelines for the routine investigation and monitoring of adult HIV\u20101 positive individuals.2019."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000445"},{"key":"e_1_2_8_14_1","unstructured":"European AIDS Clinical Society.EACS Guidelines Version 13.0.2025."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2012.04.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/656412"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2014.0205"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13170"},{"key":"e_1_2_8_19_1","unstructured":"World Health Organisation.Guidelines for pre\u2010clinical evaluation and clinical trials in osteoporosis WHO Geneva 1998. World Health Organisation.1998."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2007.11.005"},{"key":"e_1_2_8_21_1","unstructured":"FRAX Calculator. University of Sheffield.2008."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.007984"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07882-0"},{"key":"e_1_2_8_24_1","unstructured":"National Osteoporosis Guideline Group.Guideline for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50\u2009years in the UK. National Osteoporosis Guideline Group2024."}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70264","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:49:36Z","timestamp":1788749376000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,2]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/hiv.70264"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70264","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,2]]},"assertion":[{"value":"2025-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}