{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T03:08:26Z","timestamp":1788750506584,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43TW011826"],"award-info":[{"award-number":["D43TW011826"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We sought to investigate the differences and changes over time in Life's Simple 7 (LS7) and Pooled Cohort Equation (PCE) scores for cardiovascular diseases (CVD) risk by HIV status in the Mwanza HIV&amp;CVD Cohort from three outpatient, facility\u2010based HIV clinics in urban Tanzania.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Longitudinal comparative cohort study of people with HIV and people without HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>People with HIV were enrolled at HIV diagnosis before antiretroviral therapy (ART) initiation and followed after 2\u2009years of dolutegravir (DTG) exposure. The differences LS7 metrics by HIV status were measured. Each LS7 metric was categorized as ideal (2 points), intermediate (1 point) and poor (0 point). PCE risk score was categorized as low (&lt;5%), intermediate (5% to &lt;7.5%) and high (\u22657.5%). Changes over time in total LS7 score, individual LS7 metrics and PCE scores were examined in people with HIV from the pre\u2010ART to post\u2010DTG visits using ordinal logistic mixed\u2010effects regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 832 (402 people with HIV\/430 people without HIV) participants were included in this analysis. Mean age was 39 (SD 10) years and 70% were female. At the post\u2010DTG visit, mean LS7 score was 10.5 (SD 1.5), 44% of participants had ideal cardiovascular health (CVH), and mean PCE score was 2.3% (SD 3.0%). People with HIV versus people without HIV had higher odds of ideal blood pressure (BP) (adjusted odds ratio [aOR]\u2009=\u20091.50, 95% confidence interval [CI]: 1.14, 1.97), but 40% lower odds of achieving ideal physical activity (PA) (aOR\u2009=\u20090.60, 95% CI: 0.46, 0.79) during the post\u2010DTG visit. People with HIV had a smaller increase in ideal BP compared to people without HIV, despite higher overall ideal BP at both visits. Most participants had a low PCE risk, though three times higher in males compared to females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Traditional CVD risk factors like BP and PA remain similar by HIV status during the first 2\u2009years of DTG exposure. Further work is needed to encourage PA among people with HIV and incorporate BP monitoring into routine HIV care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70267","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:56:52Z","timestamp":1781481412000},"page":"1468-1478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of dolutegravir on \u2018Life's Simple 7\u2019 cardiovascular risk factors: A longitudinal analysis from Tanzania"],"prefix":"10.1111","volume":"27","author":[{"given":"Gloria J.","family":"Manyangu","sequence":"first","affiliation":[{"name":"Department of Community Health Bugando Medical Centre  Mwanza United Republic of Tanzania"},{"name":"School of Public Health, Catholic University of Health and Allied Sciences  Mwanza United Republic of Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahati","family":"Wajanga","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bugando Medical Centre  Mwanza United Republic of Tanzania"},{"name":"Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences  Mwanza United Republic of Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Desderius","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bugando Medical Centre  Mwanza United Republic of Tanzania"},{"name":"Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences  Mwanza United Republic of Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salama","family":"Fadhili","sequence":"additional","affiliation":[{"name":"National Institute for Medical Research, Mwanza Intervention Trials Unit  Mwanza United Republic of Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Willkens","sequence":"additional","affiliation":[{"name":"Center of Global Health, Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Myalla","sequence":"additional","affiliation":[{"name":"National Institute for Medical Research, Mwanza Intervention Trials Unit  Mwanza United Republic of Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godfrey A.","family":"Kisigo","sequence":"additional","affiliation":[{"name":"National Institute for Medical Research, Mwanza Intervention Trials Unit  Mwanza United Republic of Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Praygod","sequence":"additional","affiliation":[{"name":"National Institute for Medical Research  Dar es Salaam United Republic of Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Center of Global Health, Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-2480","authenticated-orcid":false,"given":"Robert N.","family":"Peck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bugando Medical Centre  Mwanza United Republic of Tanzania"},{"name":"Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences  Mwanza United Republic of Tanzania"},{"name":"National Institute for Medical Research, Mwanza Intervention Trials Unit  Mwanza United Republic of Tanzania"},{"name":"Center of Global Health, Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Kalluvya","sequence":"additional","affiliation":[{"name":"Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences  Mwanza United Republic of Tanzania"},{"name":"Research and Consultancy Unit Bugando Medical Centre  Mwanza United Republic of Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily D.","family":"Yan","sequence":"additional","affiliation":[{"name":"Center of Global Health, Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2020.02.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010017\u20104940\u20101"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25274\/full"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304146"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000678"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103018(25)00047\u20105"},{"key":"e_1_2_10_8_1","unstructured":"British HIV Association (BHIVA).BHIVA rapid guidance on the use of statins for primary prevention of cardiovascular disease in people living with HIV.2023. Accessed June 28 2025.https:\/\/bhiva.org\/file\/655cdf1d7dcb1\/BHIVA-rapid-guidance-on-the-use-of-statins.pdf"},{"key":"e_1_2_10_9_1","volume-title":"WHO Recommends Dolutegravir as Preferred HIV Treatment Option in all Populations","author":"World Health Organization","year":"2019"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz999"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215541"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101412"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2022.0063"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010014\u20100125\u20102"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpac085"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2024.2445198"},{"key":"e_1_2_10_18_1","unstructured":"WHO.Update on the transition to dolutegravir\u2010based antiretroviral therapy. 2022. Accessed June 28 2025.https:\/\/www.who.int\/publications\/i\/item\/9789240053335"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010015\u20100357\u20109"},{"key":"e_1_2_10_20_1","unstructured":"World Health Organization.The STEPS instrument and support materials. 2020.https:\/\/www.who.int\/publications\/m\/item\/standard-steps-instrument"},{"key":"e_1_2_10_21_1","volume-title":"Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia: Report of a WHO\/IDF Consultation","author":"World Health Organization","year":"2006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192703"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2016.0104"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1157"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2020.101151"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17\u2010S003"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.053730"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437741.48606.98"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.002"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103018(20)30241\u20101"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac036"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1037"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.2177"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.5334\/gh.801"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13621"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13524"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103018(23)00328\u20104"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.26216"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13975"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/frph.2023.1093298"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262298"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v18i2.25"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462416688127"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2020.01.005"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jana.2018.05.001"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.26268"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.5661"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103018(24)00276\u20105"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwab201"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70267","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:49:51Z","timestamp":1788749391000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,14]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/hiv.70267"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70267","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,14]]},"assertion":[{"value":"2025-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}