{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T03:08:26Z","timestamp":1788750506250,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cardiovascular disease (CVD) is a major comorbidity and leading cause of morbidity and mortality in people with HIV (PWH). The REPRIEVE trial demonstrated that statin therapy significantly reduces cardiovascular events in PWH, prompting updated recommendations from major international societies. We assessed awareness and early implementation of the European AIDS Clinical Society (EACS) statin guidance among HIV clinicians in Europe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted an anonymous cross\u2010sectional online survey among members of the EACS Young Investigators Network Group (YING). The questionnaire evaluated clinician characteristics, reported awareness and implementation of statin guidance, cardiovascular risk assessment practices, prescribing patterns and perceived barriers. Descriptive analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 125 individuals invited to take part in the survey, 22 (18%) physicians from multiple European countries responded. All respondents were aware of the EACS statin guidance, and 91% reported that it influenced clinical practice. Cardiovascular risk was routinely assessed by most clinicians (77% always or often), with HIV physicians primarily responsible for statin prescribing (59%). Structural barriers reported included reimbursement limitations, fragmented care pathways and patient\u2010level barriers, such as low perceived CVD risk and statin hesitancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Awareness of EACS statin guidance among this cohort of HIV clinicians in Europe who are YING members is reported as high, but implementation gaps remain. Addressing structural and patient\u2010level barriers and improving guideline implementation will be essential to optimize CVD prevention in PWH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70271","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:51:18Z","timestamp":1781790678000},"page":"1537-1547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Awareness and early implementation of the European\n                    <scp>AIDS<\/scp>\n                    Clinical Society Guidance on statin use in\n                    <scp>HIV<\/scp>\n                    for the primary prevention of cardiovascular disease: A cross\u2010sectional survey of\n                    <scp>HIV<\/scp>\n                    clinicians in Europe"],"prefix":"10.1111","volume":"27","author":[{"given":"Jasmini","family":"Alagaratnam","sequence":"first","affiliation":[{"name":"Department of HIV Medicine &amp; Sexual Health Chelsea &amp; Westminster Hospital NHS Foundation Trust  London UK"},{"name":"Section of Virology, Department of Infectious Disease Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiu","family":"Sempere","sequence":"additional","affiliation":[{"name":"HIV Unit Infectious Diseases Service, Hospital, Clinic\u2010Fundacio de recerca Clinic Barcelona \u2013 Institut de investigacions Biomediques August Pi i Sunyer  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-7455","authenticated-orcid":false,"given":"Susanne","family":"Dam Nielsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6911-8846","authenticated-orcid":false,"given":"Esteban","family":"Martinez","sequence":"additional","affiliation":[{"name":"HIV Unit Infectious Diseases Service, Hospital, Clinic\u2010Fundacio de recerca Clinic Barcelona \u2013 Institut de investigacions Biomediques August Pi i Sunyer  Barcelona Spain"},{"name":"CIBERINFEC, Instituto de Salud Carlos III  Madrid Spain"},{"name":"Reial Acad\u00e8mia de Medicina de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-013-0168-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.3728"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae609"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000695"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0219-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwab201"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304146"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(25)00047-5"},{"key":"e_1_2_9_10_1","unstructured":"Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. 2025. Accessed June 2 2026.https:\/\/clinicalinfo.hiv.gov\/en\/guidelines\/hiv-clinical-guidelines-adult-and-adolescent-arv\/statin-therapy-people-hiv"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS\u201024\u201003564"},{"key":"e_1_2_9_12_1","unstructured":"WatersL GilleeceY AlagaratnamJ et al.BHIVA rapid guidance on the use of statins for primary prevention of cardiovascular disease in people living with HIV v2. 2024. Accessed October 22 2024.https:\/\/www.bhiva.org\/file\/655cdf1d7dcb1\/BHIVA-rapid-guidance-on-the-use-of-statins.pdf"},{"key":"e_1_2_9_13_1","unstructured":"GalindoMJ BernalE BernardinoJI et al.Documento de posicionamiento sobre el uso de estatinas en la prevencion primaria cardiovascular de las personas con VIH. 2024.https:\/\/gesida-seimc.org\/wp-content\/uploads\/2024\/06\/documento-de-posicionamiento-del-ensayo-clinico-REPRIEVE-DEFINITIVO.pdf"},{"key":"e_1_2_9_14_1","unstructured":"European AIDS Clinical Society (EACS).European AIDS Clinical Society. Young Investigators Network Group (YING).https:\/\/www.eacsociety.org"},{"key":"e_1_2_9_15_1","first-page":"75","article-title":"Impact of REPRIEVE indications on statin prescription in people with HIV in a real\u2010life setting","volume":"26","author":"Papaioannu Borjesson R","year":"2025","journal-title":"HIV Med"},{"key":"e_1_2_9_16_1","first-page":"5","article-title":"Statin initiation following the REPRIEVE trial: results of a clinical audit at an urban sexual health clinic in Sydney, Australia","volume":"26","author":"Burdon R","year":"2025","journal-title":"HIV Med"},{"key":"e_1_2_9_17_1","first-page":"112","article-title":"LDL target achievement in people with HIV over 40: impact of updated EACS guidelines","volume":"26","author":"Carrozzo G","year":"2025","journal-title":"HIV Med"},{"key":"e_1_2_9_18_1","first-page":"110","article-title":"Implementation of EACS 2023 cardiovascular prevention guidance in a real\u2010life HIV metabolic clinic: a longitudinal cohort study from Modena","volume":"26","author":"Manicardi M","year":"2025","journal-title":"HIV Med"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u201014\u2010783"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20101293.2010.00901.x"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:48:49Z","timestamp":1788749329000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/hiv.70271"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70271","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]},"assertion":[{"value":"2026-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}