{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:12:04Z","timestamp":1784632324086,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Peer interventions may improve retention across the prevention of mother\u2010to\u2010child transmission (PMTCT) cascade in low\u2010 and middle\u2010income countries (LMICs), where poor adherence to antiretroviral therapy (ART) remains a major barrier. This systematic review and meta\u2010analysis evaluated the impact of peer support interventions on PMTCT outcomes to inform scalable strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Following PRISMA guidelines, we searched PubMed, Cochrane Library, Scopus and Google Scholar (2008\u20132025) using terms including \u2018peer mentors,\u2019 \u2018PMTCT\u2019 and \u2018LMICs.\u2019 Independent reviewers conducted data extraction and quality appraisal using Cochrane risk\u2010of\u2010bias tools. Random\u2010effects meta\u2010analysis was performed in R (v4.4.3), with significance set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05. Qualitative findings were thematically synthesized.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010seven studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926\u2009431) across 10 countries were included. Peer interventions improved ART adherence at one year (OR: 1.19, 95% CI: 1.05\u20131.35) and two years (OR: 2.04, 95% CI: 1.58\u20132.64), PMTCT retention at six weeks postpartum (OR: 2.63, 95% CI: 1.56\u20134.43), infant uptake of HIV prophylaxis (OR: 2.95, 95% CI: 1.90\u20134.59), early infant diagnosis (OR: 1.64, 95% CI: 1.01\u20132.67) and viral load testing (OR: 1.21, 95% CI: 1.07\u20131.38). No significant effects were observed for ART initiation, PMTCT retention at 12\u2009months or HIV status disclosure. Most studies (75%) reported improved exclusive breastfeeding. Barriers included stigma, inadequate mentor training, logistical and economic constraints and poor male involvement; facilitators included training, incentives and community trust.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Peer interventions improve adherence, infant prophylaxis and retention but have limited effects on viral suppression and disclosure. Addressing stigma, strengthening health systems and enhancing male engagement may optimize impact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70285","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:35:26Z","timestamp":1784630126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the impact, barriers and facilitators of peer\u2010driven interventions on the prevention of mother\u2010to\u2010child transmission of\n                    <scp>HIV<\/scp>\n                    in low\u2010 and middle\u2010income countries: A systematic review and meta\u2010analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2747-1681","authenticated-orcid":false,"given":"Victor Oluwafemi","family":"Femi\u2010Lawal","sequence":"first","affiliation":[{"name":"College of Medicine University of Ibadan  Ibadan 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