{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:58:07Z","timestamp":1790927887145,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 AI068634"],"award-info":[{"award-number":["UM1 AI068634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 AI068636"],"award-info":[{"award-number":["UM1 AI068636"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 AI106701"],"award-info":[{"award-number":["UM1 AI106701"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We have shown that semaglutide, a glucagon\u2010like peptide\u20101 receptor agonist (GLP\u20101RA), is a highly effective therapy for metabolic dysfunction\u2010associated steatotic liver disease (MASLD) in people with HIV (PWH). The OWLiver\u00ae metabolomics algorithms allow non\u2010invasive MASLD severity staging without liver biopsy, but the use of metabolomic data for disease monitoring with GLP\u20101RA therapy has not been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      SLIM LIVER (ACTG A5371) was an open\u2010label, phase 2b, single\u2010arm trial of semaglutide in PWH and MASLD (2021\u20132022). Adult participants who showed clinical response (&gt;2.27\u2009kg weight loss) to semaglutide during the study (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200936) had their serum analysed for metabolomic profiling by the OWLiver\u00ae panel.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010four weeks of low\u2010dose semaglutide led to significant improvement in MASLD disease severity by serum metabolomic profiling across all MASLD disease severity categories, suggesting histologic improvements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The OWLiver\u00ae metabolomics algorithms can be used to monitor MASLD severity during GLP\u20101RA therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70292","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:22:20Z","timestamp":1785241340000},"page":"1710-1714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Semaglutide improves\n                    <scp>MASLD<\/scp>\n                    and\n                    <scp>MASH<\/scp>\n                    in people with\n                    <scp>HIV<\/scp>\n                    : The\n                    <scp>SLIM LIVER<\/scp>\n                    study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-5514","authenticated-orcid":false,"given":"Jordan E.","family":"Lake","sequence":"first","affiliation":[{"name":"Department of Internal Medicine UTHealth Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7999-8912","authenticated-orcid":false,"given":"Douglas W.","family":"Kitch","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kantor","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Mayo","sequence":"additional","affiliation":[{"name":"Rubi\u00f3 Metabolomics  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-4734","authenticated-orcid":false,"given":"Pablo","family":"Belaunzaran\u2010Zamudio","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases (NIAID)  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6778-7253","authenticated-orcid":false,"given":"Carl J.","family":"Fichtenbaum","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-278X","authenticated-orcid":false,"given":"Todd T.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen E.","family":"Corey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Sattler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0808-6729","authenticated-orcid":false,"given":"Kristine M.","family":"Erlandson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.70256"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1188"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000000542"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.70376"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/M23\u20103354"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000313"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000001477"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.70292","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.70292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:51:18Z","timestamp":1790927478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.70292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/hiv.70292"],"URL":"https:\/\/doi.org\/10.1111\/hiv.70292","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"2026-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}