{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:58:10Z","timestamp":1790927890562,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Frailty is relevant to HIV care across middle and later life, yet Japanese data remain limited. We evaluated frailty, prefrailty and associated factors in Japanese people with HIV using the revised Japanese Cardiovascular Health Study (J\u2010CHS) criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicentre cross\u2010sectional study at eight HIV care centres. Eligible participants were Japanese people with HIV aged \u226540\u2009years on antiretroviral therapy for \u226512\u2009months. Frailty was classified as robust, prefrail or frail. Multivariable logistic regression examined factors associated with frailty\u2010related outcomes; sensitivity analyses excluded sex from the model and restricted analyses to men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 325 participants, median age was 55 [49\u201364] years and 311 (95.7%) were male; 70 (21.5%) were robust, 227 (69.8%) prefrail and 28 (8.6%) frail. Common components were low physical activity (36.6%), weight loss (33.2%) and slow gait (27.1%). In the frailty versus non\u2010frailty model, higher PHQ\u20109 score (adjusted odds ratio [aOR] 1.12 per point, 95% confidence interval [CI] 1.04\u20131.21) and polypharmacy (aOR 3.34, 95% CI 1.23\u20139.10) were associated with frailty. In the prefrailty\/frailty versus robust model, higher PHQ\u20109 score and body mass index were associated with the outcome. Sensitivity analyses yielded broadly consistent findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prefrailty was highly prevalent, and frailty was associated with depressive symptoms and polypharmacy. Frailty at a median age of 55\u2009years suggests clinically relevant vulnerability in Japanese people with HIV, although longitudinal and comparative studies are needed. These findings support integrated HIV care combining mental\u2010health screening, medication review and physical\u2010function assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70297","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:22:54Z","timestamp":1786101774000},"page":"1670-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Frailty and associated clinical factors among Japanese people with\n                    <scp>HIV<\/scp>\n                    : A multicentre cross\u2010sectional study using the revised Japanese Cardiovascular Health Study criteria"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7686-4604","authenticated-orcid":false,"given":"Hideta","family":"Nakamura","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, Division of Infectious, Respiratory, and Digestive Medicine University of the Ryukyus Graduate School of Medicine  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Falutz","sequence":"additional","affiliation":[{"name":"McGill University Health Centre, McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2133-2214","authenticated-orcid":false,"given":"Taro","family":"Naka","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation University of the Ryukyus Hospital  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Miyamori","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation University of the Ryukyus Hospital  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanae","family":"Ikemiyagi","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Division of Infectious, Respiratory, and Digestive Medicine University of the Ryukyus Graduate School of Medicine  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Yamaniha","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Division of Infectious, Respiratory, and Digestive Medicine University of the Ryukyus Graduate School of Medicine  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Ideguchi","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Division of Infectious, Respiratory, and Digestive Medicine University of the Ryukyus Graduate School of Medicine  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5847-4108","authenticated-orcid":false,"given":"Rumi","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Clinical Research Institute, NHO Kyushu Medical Center  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Narita","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine Okinawa Prefectural Nanbu Medical Center and Children's Medical Center  Haebaru Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinori","family":"Shirano","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Osaka City General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei","family":"Samukawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Clinical Immunology Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Prevention 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