{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T10:30:44Z","timestamp":1793615444923,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the prevalence of polypharmacy, drug\u2013drug interactions (DDIs), potential prescribing omissions (PPOs) and potentially inappropriate medications (PIMs) among people living with Human Immunodeficiency Virus (HIV) aged \u226550\u2009years and to evaluate their association with quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional analytical study was conducted between March and May 2025 at a tertiary infectious disease clinic. A total of 141 people living with HIV aged \u226550\u2009years who were receiving antiretroviral therapy (ART) and under active follow\u2010up were included. DDIs were assessed using the Liverpool HIV Drug Interactions database, while PPOs and PIMs were evaluated using the TIME\u2010to\u2010START and TIME\u2010to\u2010STOP criteria. Quality of life was assessed using the PozQoL scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Polypharmacy was identified in 42 participants (29.8%) and DDIs in 22 (15.6%). Although PPOs were initially identified in all participants according to TIME\u2010to\u2010START criteria, this was largely driven by vaccination\u2010related items. Vaccination\u2010related items were excluded when evaluating the association between PPOs and quality of life, and the prevalence of PPOs decreased to 32.6%. PIMs were detected in 16.3%. Polypharmacy was associated with low quality of life in the health concern domain (OR 3.52, 95% CI 1.34\u20139.27). DDIs were associated with low overall (OR 7.65, 95% CI 2.01\u201329.07) and psychological quality of life (OR 14.55, 95% CI 3.45\u201361.37). PPOs were associated with low psychological (OR 10.67, 95% CI 2.80\u201340.68) and health concern domains (OR 3.19, 95% CI 1.27\u20138.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Medication\u2010related problems were common among older people living with HIV. Polypharmacy, DDIs and PPOs were associated with impaired quality of life, highlighting the need for structured medication review and multidisciplinary care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70301","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:45:10Z","timestamp":1787787910000},"page":"1802-1813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Medication burden and prescribing quality in older people living with\n                    <scp>HIV<\/scp>\n                    : Associations with quality of life"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8162-2865","authenticated-orcid":false,"given":"Abdulkadir","family":"Sonkaya","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Haydarpasa Numune Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6886-8266","authenticated-orcid":false,"given":"Nurg\u00fcl","family":"Ceran","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Haydarpasa Numune Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-6613","authenticated-orcid":false,"given":"Seniha","family":"\u015eenbayrak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Haydarpasa Numune Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6182-1262","authenticated-orcid":false,"given":"Asuman","family":"Inan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Haydarpasa Numune Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-3665","authenticated-orcid":false,"given":"Serpil","family":"Erol","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Haydarpasa Numune Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2942-2525","authenticated-orcid":false,"given":"Recep","family":"Balik","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Haydarpasa Numune Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9952-1721","authenticated-orcid":false,"given":"Vahibe","family":"Aydin Sarikaya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Haydarpasa Numune Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Special Populations: HIV and the Older Person. NIH Clinical Info [Internet]. 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