{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:01:54Z","timestamp":1789639314367,"version":"4.0.0"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["CO\u2010ES\u2010380\u20106743"],"award-info":[{"award-number":["CO\u2010ES\u2010380\u20106743"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on adults aged \u226560\u2009years with HIV remain limited, despite their increasing representation in clinical practice. We evaluated whether age \u226560\u2009years was associated with reasons for treatment switch, quality of life (QoL) and clinical outcomes among adults with HIV switching antiretroviral therapy in routine care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a cross\u2010sectional analysis of prospectively collected data from a real\u2010world cohort established in 2018, including adults with HIV aged \u226550\u2009years who switched to bictegravir\u2010based three\u2010drug regimens (BIC 3DR) or dolutegravir\u2010based two\u2010drug regimens (DTG 2DR). Participants were stratified by age (\u226560 vs. &lt;60\u2009years). Outcomes included reasons for treatment switch, incident comorbidity and self\u2010reported QoL. QoL was analysed as both ordinal and dichotomous (favourable vs. non\u2010favourable). Multivariable analyses were adjusted for treatment strategy, sex and HIV acquisition route.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The distribution of reasons for treatment switch differed by age within the DTG 2DR group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), but not within the BIC 3DR group. In the DTG 2DR group, toxicity or adverse events accounted for 5.6% of switches among participants aged &lt;60\u2009years and 21.7% among those aged \u226560\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), with a significant age\u2010group\u2010by\u2010treatment\u2010strategy interaction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Age \u226560\u2009years was independently associated with higher odds of favourable QoL (adjusted odds ratio [OR] 2.88, 95% confidence interval [CI] 1.15\u20137.24), with no interaction by treatment. No significant differences were observed in incident hypertension, type 2 diabetes mellitus or dyslipidemia in time\u2010to\u2010event analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among adults with HIV switching antiretroviral therapy, age \u226560\u2009years was associated with differences in the distribution of reasons for treatment switch and with better perceived QoL, but not with differences in clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70310","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:02:44Z","timestamp":1789635764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of life among older adults with\n                    <scp>HIV<\/scp>\n                    after switching to bictegravir\u2010based three\u2010drug or dolutegravir\u2010based two\u2010drug regimens"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-5382","authenticated-orcid":false,"given":"F\u00e1tima","family":"Bra\u00f1as","sequence":"first","affiliation":[{"name":"Hospital Universitario Infanta Leonor  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-4071","authenticated-orcid":false,"given":"M. Jos\u00e9","family":"Galindo","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-7405","authenticated-orcid":false,"given":"Miguel","family":"Torralba","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Guadalajara  Guadalajara Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Antela","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-813X","authenticated-orcid":false,"given":"Mar\u00eda Luisa","family":"Montes","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Jes\u00fas","family":"Bustinduy","sequence":"additional","affiliation":[{"name":"Hospital Universitario Donostia  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7259-554X","authenticated-orcid":false,"given":"Noem\u00ed","family":"Cabello","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8429-8358","authenticated-orcid":false,"given":"Alfonso","family":"Cabello","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-0114","authenticated-orcid":false,"given":"Margarita","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-7419","authenticated-orcid":false,"given":"Pablo","family":"Ryan","sequence":"additional","affiliation":[{"name":"Hospital Universitario Infanta Leonor  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Bustingorri","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3343-0085","authenticated-orcid":false,"given":"Isabel","family":"Machuca","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3880-199X","authenticated-orcid":false,"given":"Matilde","family":"S\u00e1nchez\u2010Conde","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"},{"name":"CIBERINFEC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00056-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-022-03719-8"},{"key":"e_1_2_9_4_1","first-page":"407","article-title":"Effectiveness and safety of bictegravir\/emtricitabine\/tenofovir alafenamide in people with HIV: a real\u2010world data from the Spanish BICSTaR Cohort","volume":"17","author":"Inciarte A","year":"2025","journal-title":"HIV AIDS 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