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<jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Utilizing a nested exposure\u2010matched study of people with HIV age 18\u2009years, on antiretroviral therapy from the NA\u2010ACCORD and the Mass General Brigham HIV cohorts between 01\/1\/2014 and 12\/31\/2022, people with HIV with HCV co\u2010infection were identified by detectable plasma HCV RNA. People with HIV who initiated DAA were matched 1:1 with people with HIV who did not initiate DAA. Multivariable linear regression models estimated HbA1c (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20092374), TC (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20093418) and ASCVD risk score (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009488) at 12\u2010months comparing people with HIV who initiated DAAs versus did not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified no significant difference in the mean HbA1c at 12\u2010months comparing DAA initiators to DAA non\u2010initiators (\u03b2: 0.00%, 95% confidence interval [CI] \u22120.09% to 0.08%). The mean TC at 12\u2010months was 13\u2009mg\/dL (95% CI 11\u201316\u2009mg\/dL) higher in DAA initiators and largely due to increases in LDL. There was no significant difference in the mean ASCVD risk score at 12\u2010months when comparing DAA initiators with those who did not initiate DAAs (\u03b2: 1.10, 95% CI \u22120.09 to 2.20).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>People with HIV with HCV who initiated DAA demonstrated no statistically significant difference in HbA1c or ASCVD risk score at 12\u2010months compared to HIV\/HCV co\u2010infected persons who did no initiate DAA. However, TC and LDL levels increased 12 months following DAA treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70325","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:57:33Z","timestamp":1792378653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in cardiometabolic biomarkers 1\u2009year after direct acting antiviral therapy for hepatitis C virus co\u2010infection among people with\n                    <scp>HIV<\/scp>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0268-4680","authenticated-orcid":false,"given":"Raynell","family":"Lang","sequence":"first","affiliation":[{"name":"Department of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Humes","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asya","family":"Lyass","sequence":"additional","affiliation":[{"name":"Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7498-4450","authenticated-orcid":false,"given":"Leila H.","family":"Borowsky","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-8910","authenticated-orcid":false,"given":"Brenna","family":"Hogan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8488-5170","authenticated-orcid":false,"given":"Michael","family":"LaValley","sequence":"additional","affiliation":[{"name":"Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5650-4310","authenticated-orcid":false,"given":"Jennifer O.","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Pleasanton California USA"},{"name":"Division of Health Systems Science Kaiser Permanente Bernard J. Tyson School of Medicine  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6021-9176","authenticated-orcid":false,"given":"Ditipriya","family":"Bhar","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine Johns Hopkins School of Medicine  Baltimore Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Palella","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Crane","sequence":"additional","affiliation":[{"name":"Division of Allergy and Infectious Diseases, Departments of Medicine and Epidemiology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Horberg","sequence":"additional","affiliation":[{"name":"Mid\u2010Atlantic Permanente Research Institute Kaiser Permanente Mid\u2010Atlantic Permanente Medical Group  Rockville Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Napravnik","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Epidemiology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia A.","family":"Triant","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of General 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