{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:38:37Z","timestamp":1792492717960,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite growing availability of HIV pre\u2010exposure prophylaxis (PrEP), many potential users turn to online forums for advice and information collection. These forums provide a window into real\u2010world questions, concerns and misinformation. They serve as a tool for users to query for sensitive information without revealing their identities. These platforms could therefore be a potential source of understanding of the unmet needs of users. This study systematically analyses the social media posts referring to the four drugs mentioned in the study to identify common questions and thematic concerns among the community and uses this insight to inform the design of an AI\u2010driven, privacy\u2010preserving chatbot for PrEP education based on evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between May 2011 to October 2025, we found 1168 relevant Reddit posts mentioning one of the four names for PrEP therapies, by either brand or generic name: Truvada (Tenofovir disoproxil fumarate + emtricitabine (TDF\/FTC)), Descovy (Tenofovir alafenamide + emtricitabine (TAF\/FTC)), Apretude (long\u2010acting cabotegravir), Yeztugo (lenacapavir) using a systematic search. We used Natural Language processing (NLP) techniques to understand user needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven distinct discussion themes were identified within PrEP social media discourse, with side effects emerging as the most frequently discussed primary topic among 1076 posts. Across all medications, weight changes were the most frequently mentioned side effect. Truvada was the most frequently discussed PrEP medication. 96.7% of the dataset comprised questions, showing that Reddit serves as a primary information\u2010seeking platform. Early period discussions were emphasized basic access and effectiveness questions, with more recent discussions (2022\u20132025) displaying increased attention to injectable and long\u2010term safety considerations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Reddit users demonstrate persistent uncertainty about PrEP side effects, drug interactions and medication switching. Drug interactions represented the most frequently identified information gap (26.5% of posts). These empirically derived information needs will inform the design of a privacy\u2010preserving PrEP chatbot trained on authoritative UK sources (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/hiv-druginteractions.org\">hiv-druginteractions.org<\/jats:ext-link>\n                      , BHIVA guidelines, NHS resources).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.70332","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:41:46Z","timestamp":1792489306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Understanding community questions about\n                    <scp>HIV<\/scp>\n                    pre\u2010exposure prophylaxis (\n                    <scp>PrEP<\/scp>\n                    ): A thematic analysis of reddit threads to inform development of an\n                    <scp>AI<\/scp>\n                    chatbot for\n                    <scp>PrEP<\/scp>\n                    education"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9511-6210","authenticated-orcid":false,"given":"Alexandar","family":"Vincent\u2010Paulraj","sequence":"first","affiliation":[{"name":"Centre for Experimental Therapeutics (TherEx), University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wood","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics (TherEx), University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2312-7050","authenticated-orcid":false,"given":"Catia","family":"Marzolini","sequence":"additional","affiliation":[{"name":"Service of Clinical Pharmacology, University Hospital of Lausanne and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8063-6399","authenticated-orcid":false,"given":"Justin","family":"Chiong","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics (TherEx), University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2288-7020","authenticated-orcid":false,"given":"Daryl","family":"Hodge","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics (TherEx), University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics (TherEx), University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2778-644X","authenticated-orcid":false,"given":"Daniel","family":"Seddon","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics (TherEx), University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Martin","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics (TherEx), University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-0967","authenticated-orcid":false,"given":"Saye","family":"Khoo","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics (TherEx), University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Waker","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics (TherEx), University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Pre\u2010Exposure Prophylaxis (PrEP) | NIH [Internet]. 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[cited 2026 Jul 31]. Available from:http:\/\/apps.who.int\/bookorders"},{"key":"e_1_2_12_34_1","unstructured":"Full report \u2014 In Danger: UNAIDS Global AIDS Update 2022 | UNAIDS. [Internet]. [cited 2026 Jul 31]. 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