{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:54:51Z","timestamp":1781524491504,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Synopsis<\/jats:title><jats:p>Dandruff is a global consumer problem, characterized by flaking and scaling of the scalp, accompanied by itch and irritancy. However, the aetiology of the condition remains poorly understood, although there is a strong consensus that the cutaneous fungi <jats:italic>Malassezia globosa<\/jats:italic> and <jats:italic>M.\u00a0restricta<\/jats:italic> are a major contributory factor. Although there is a paucity of understanding on how these commensal microorganisms adopt a pathogenic phenotype, a rich source of potential insights now exists in the shape of the recently published whole\u2010genome sequence of <jats:italic>M.\u00a0globosa<\/jats:italic>, a functional annotation and metabolic reconstruction of which is freely accessible via the integrated microbial genomes (<jats:styled-content style=\"fixed-case\">IMG<\/jats:styled-content>) online community resource (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.hmpdacc-resources.org\/cgi-bin\/imgm_hmp\/main.cgi\">http:\/\/www.hmpdacc-resources.org\/cgi-bin\/imgm_hmp\/main.cgi<\/jats:ext-link>). In these studies, we have taken a combined in\u2010silico and in\u2010vitro approach to investigate aspects of lipid and amino acid metabolism by <jats:italic>M.\u00a0globosa<\/jats:italic> and <jats:italic>M.\u00a0restricta<\/jats:italic> that have the potential to impact on scalp condition and dandruff. The <jats:styled-content style=\"fixed-case\">IMG<\/jats:styled-content> platform was employed to analyse the metabolism of triacylglycerols and fatty acids, as well as the aromatic amino acid tryptophan, by <jats:italic>M.\u00a0globosa<\/jats:italic>, to investigate pro\u2010inflammatory pathways linked in the literature to dandruff and pityriasis versicolour, respectively. Results were equivocal, leaving question marks over the ability of <jats:italic>M.\u00a0globosa<\/jats:italic> to fully degrade unsaturated fatty acids and metabolize tryptophan to indole\u20103\u2010pyruvic acid. In\u2010vitro assay systems were then developed to study the biotransformation of these metabolites by both <jats:italic>M.\u00a0globosa<\/jats:italic> and <jats:italic>M.\u00a0restricta<\/jats:italic>, as well as their effect on human keratinocytes, and the results here indicated that neither unsaturated fatty acids nor indole derivatives are likely to be major aetiological factors in dandruff.<\/jats:p>","DOI":"10.1111\/ics.12022","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T15:26:47Z","timestamp":1351178807000},"page":"169-175","source":"Crossref","is-referenced-by-count":35,"title":["Metabolic analysis of the cutaneous fungi <i>Malassezia globosa<\/i> and <i>M.\u00a0restricta<\/i> for insights on scalp condition and dandruff"],"prefix":"10.1111","volume":"35","author":[{"given":"A.","family":"Gordon James","sequence":"first","affiliation":[{"name":"Unilever Discover Colworth Science Park Sharnbrook Bedford MK44 1LQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen H.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Unilever Discover Colworth Science Park Sharnbrook Bedford MK44 1LQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana S.","family":"Cox","sequence":"additional","affiliation":[{"name":"Unilever Discover Colworth Science Park Sharnbrook Bedford MK44 1LQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison E.","family":"Moore","sequence":"additional","affiliation":[{"name":"Unilever Discover Colworth Science Park Sharnbrook Bedford MK44 1LQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Pople","sequence":"additional","affiliation":[{"name":"Unilever Discover Colworth Science Park Sharnbrook Bedford MK44 1LQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1201\/b14191-22"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1997.d01-231.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00723.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10119.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb04050.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00399623"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.1.21-57.2002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.034"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706756104"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10104.x"},{"key":"e_1_2_6_12_1","first-page":"AB133","article-title":"Malassezia require saturated, not unsaturated, fatty acids for growth: role of Malassezia lipid metabolism in seborrheic dermatitis (dandruff)","volume":"54","author":"Dawson T.","year":"2006","journal-title":"J. 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