{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:03:34Z","timestamp":1791421414645,"version":"4.3.3"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T00:00:00Z","timestamp":1360800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Synopsis<\/jats:title><jats:p>Since ancient times, human beings have been trying to protect their skin against the adverse effects of the sun. From the first mineral sunscreens used by Egyptians, to the current more sophisticated ultraviolet (<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>) organic sunscreens, progress has been made in terms of sun protection and deeper knowledge of skin physiology has been acquired in the process. The solar spectrum is composed of radiations of various wavelengths having specific, as well as overlapping effects on skin. <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> is mainly responsible for sunburn and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> dimer formation that can lead to mutation. <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> generates oxidative reactions affecting <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, proteins and lipids, and is also immunosuppressive. Recently, visible light and infrared radiation (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) have been associated with oxidative damage and <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> has been additionally linked to adverse heat effects on skin. Numerous other extrinsic factors, related to environment and lifestyle, also affect the appearance of skin, precipitating ageing. New molecular mechanisms linking sun and environmental factors to skin ageing have been identified: <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> affects mitochondrial integrity and specific heat receptors also mediate some of its effects, tryptophan is a chromophore for <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>, and the aryl hydrocarbon receptor (AhR) is activated by light and xenobiotics to alter skin physiology. Integrating all these new elements is changing the way we think about skin extrinsic ageing. Is <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> sunscreen protection still enough for our skin?<\/jats:p>","DOI":"10.1111\/ics.12036","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T07:15:01Z","timestamp":1360826101000},"page":"224-232","source":"Crossref","is-referenced-by-count":171,"title":["Beyond <scp>UV<\/scp> radiation: A skin under challenge"],"prefix":"10.1111","volume":"35","author":[{"given":"E.","family":"Dupont","sequence":"first","affiliation":[{"name":"Immanence IDC Inc 3229 ch. Quatre\u2010Bourgeois, bureau 600 Qu\u00e9bec Qu\u00e9bec G1W 0C1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Immanence IDC Inc 3229 ch. Quatre\u2010Bourgeois, bureau 600 Qu\u00e9bec Qu\u00e9bec G1W 0C1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bilodeau","sequence":"additional","affiliation":[{"name":"CosmeConsult 174 Rue 9<sup>e<\/sup> Qu\u00e9bec Qu\u00e9bec G1L 2N1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,14]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/9781420019964-1"},{"key":"e_1_2_4_3_1","doi-asserted-by":"crossref","first-page":"53S","DOI":"10.1038\/jid.1989.33","article-title":"Pigment Cell Biology: an Historical Review","volume":"92","author":"Nordlund J.J.","year":"1989","journal-title":"J. Invest. Dermatol."},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1969.03160390039008"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12510322"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00509050"},{"key":"e_1_2_4_7_1","first-page":"215","article-title":"The nature of photoaging: its prevention and repair","volume":"3","author":"Kligman L.H.","year":"1986","journal-title":"Photodermatol."},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1562\/2006-02-08-RA-799"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.204"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-89656-2_92"},{"key":"e_1_2_4_11_1","first-page":"50","article-title":"From hydration to cell turnover: an integral approach to anti\u2010aging","volume":"125","author":"Dupont E.","year":"2010","journal-title":"Cosmetics & Toiletries."},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553002.2010.501842"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/315207a0"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0pp90034f"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-012-1212-x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00764.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1pp05142c"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.08.011"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1pp05144j"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10161.x"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2011.08.002"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000188083"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.476"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00286.x"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.11.009"},{"key":"e_1_2_4_26_1","first-page":"1275","article-title":"Effects of UV and visible radiation on DNA\u2010final base damage","volume":"378","author":"Cadet J.","year":"1997","journal-title":"Biol. Chem."},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.4.811"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.95"},{"key":"e_1_2_4_29_1","first-page":"149","article-title":"Visible light photopatch testing of common photocontactants in female filipino adults with and without melasma: a cross\u2010sectional study","volume":"7","author":"Verallo\u2010Rowell V.M.","year":"2008","journal-title":"J. Drugs Dermatol."},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1pp05202k"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2008.04.010"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2009.1"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-89656-2_42"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.394"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.03.031"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.piel.2011.01.012"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000257259"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-1637(02)00024-7"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.116"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01851.x"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2012.01.006"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.11.003"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2009.7"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.8"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00806.x"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2009.13"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.85"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1515\/bc.2010.128"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.4032007pe49"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.269"},{"key":"e_1_2_4_51_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2011.614947"},{"key":"e_1_2_4_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-89656-2_45"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1270416"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1pp05186e"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/858425"},{"key":"e_1_2_4_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25576"},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2011.651719"},{"key":"e_1_2_4_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2010.00838.x"},{"key":"e_1_2_4_59_1","first-page":"25","article-title":"A whiter shade of pale in skin care","volume":"2011","author":"Dupont E.","year":"2011","journal-title":"Personal. Care. Asia. Pacific. Jan"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.04.012"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e318214ea2d"}],"container-title":["International Journal of Cosmetic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fics.12036","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.12036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T07:16:54Z","timestamp":1698650214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ics.12036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,14]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/ics.12036"],"URL":"https:\/\/doi.org\/10.1111\/ics.12036","archive":["Portico"],"relation":{},"ISSN":["0142-5463","1468-2494"],"issn-type":[{"value":"0142-5463","type":"print"},{"value":"1468-2494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,14]]}}}