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The recent identification of loss\u2010of\u2010function filaggrin (\n                    <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>\n                    ) mutations as a predisposing factor in ichthyosis vulgaris and atopic dermatitis has lead to a resurgent interest in this enigmatic protein. Here, we review the literature on the structure and many functions of pro\n                    <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>\n                    , from its role as a filament\u2010aggregating protein and a source of natural moisturizing factor (\n                    <jats:styled-content style=\"fixed-case\">NMF<\/jats:styled-content>\n                    ), to the more recent discoveries of its role in epidermal barrier formation and its more speculative functions as an antimicrobial and sunscreen. Finally, we discuss the relationship of pro\n                    <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>\n                    with dry skin, the influence of moisturizers on\n                    <jats:styled-content style=\"fixed-case\">NMF<\/jats:styled-content>\n                    generation and speculate on next generation of\n                    <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>\n                    research.\n                  <\/jats:p>","DOI":"10.1111\/ics.12049","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T03:48:41Z","timestamp":1363837721000},"page":"412-423","source":"Crossref","is-referenced-by-count":78,"title":["Filaggrin \u2013 revisited"],"prefix":"10.1111","volume":"35","author":[{"given":"C. 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